TY - JOUR
T1 - Functional MR Imaging
T2 - Blood Oxygen Level–Dependent and Resting State Techniques in Mild Traumatic Brain Injury
AU - Rosenthal, Scott
AU - Gray, Matthew
AU - Fatima, Hudaisa
AU - Sair, Haris I.
AU - Whitlow, Christopher T.
PY - 2018/2
Y1 - 2018/2
N2 - This article discusses mild traumatic brain injury (mTBI)-associated effects on brain functional connectivity assessed via resting-state functional MR (fMR) imaging. Several studies have reported acute post-injury default mode network hyperconnectivity, followed by a period of decreased connectivity before later connectivity normalization in some patients. Other studies have reported mTBI associated effects on connectivity that remain evident for up to 5-years or more. Discordance in the published literature regarding the direction of network connectivity changes (eg, increased versus decreased connectivity) may reflect differences in timing of data collection post-injury, as well as the need to standardize MR imaging acquisition protocols and processing methods.
AB - This article discusses mild traumatic brain injury (mTBI)-associated effects on brain functional connectivity assessed via resting-state functional MR (fMR) imaging. Several studies have reported acute post-injury default mode network hyperconnectivity, followed by a period of decreased connectivity before later connectivity normalization in some patients. Other studies have reported mTBI associated effects on connectivity that remain evident for up to 5-years or more. Discordance in the published literature regarding the direction of network connectivity changes (eg, increased versus decreased connectivity) may reflect differences in timing of data collection post-injury, as well as the need to standardize MR imaging acquisition protocols and processing methods.
KW - Blood oxygen level dependent
KW - Functional MR imaging
KW - Mild traumatic brain injury
KW - Resting state
UR - http://www.scopus.com/inward/record.url?scp=85035326005&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85035326005&partnerID=8YFLogxK
U2 - 10.1016/j.nic.2017.09.008
DO - 10.1016/j.nic.2017.09.008
M3 - Review article
C2 - 29157847
AN - SCOPUS:85035326005
SN - 1052-5149
VL - 28
SP - 107
EP - 115
JO - Neuroimaging Clinics of North America
JF - Neuroimaging Clinics of North America
IS - 1
ER -