Functional, Morphological, and Evolutionary Characterization of Hearing in Subterranean, Eusocial African Mole-Rats

Sonja J. Pyott, Marcel van Tuinen, Laurel A. Screven, Katrina M. Schrode, Jun Ping Bai, Catherine M. Barone, Steven D. Price, Anna Lysakowski, Maxwell Sanderford, Sudhir Kumar, Joseph Santos-Sacchi, Amanda M. Lauer, Thomas J. Park

Research output: Contribution to journalArticlepeer-review

Abstract

Pyott et al. attribute comparatively poor hearing in African naked and Damaraland mole-rats to lack of cochlear amplification, disrupted hair bundles, and hair bundle proteins bearing deafness-associated amino acid substitutions. Positive selection in some bundle proteins suggests altered hearing is adaptive to subterranean and eusocial lifestyles.

Original languageEnglish (US)
Pages (from-to)4329-4341.e4
JournalCurrent Biology
Volume30
Issue number22
DOIs
StatePublished - Nov 16 2020

Keywords

  • adaptive
  • auditory outer hair cells
  • cochlea
  • cochlear amplifier
  • deafness
  • evolution
  • hair bundle
  • prestin
  • selection
  • stereocilia

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)

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