TY - JOUR
T1 - Functional magnetic resonance imaging outcomes from a comprehensive magnetic resonance study of children with fetal alcohol spectrum disorders
AU - Astley, Susan J.
AU - Aylward, Elizabeth H.
AU - Olson, Heather Carmichael
AU - Kerns, Kimberly
AU - Brooks, Allison
AU - Coggins, Truman E.
AU - Davies, Julian
AU - Dorn, Susan
AU - Gendler, Beth
AU - Jirikowic, Tracy
AU - Kraegel, Paul
AU - Maravilla, Kenneth
AU - Richards, Todd
N1 - Funding Information:
Acknowledgments This research was supported by NIAAA grant R01-AA12915-01 A1 to SJA. Support was also received from the Center on Human Development and Disability, University of Washington (National Institute of Child Health and Human Development grant P30 HD02274). Special thanks are extended to the children and their families who so kindly contributed time and effort to this study.
PY - 2009
Y1 - 2009
N2 - A comprehensive neuropsychological/psychiatric, MR imaging, (MRI), MR spectroscopy (MRS), and functional MRI (fMRI) assessment was administered to children with fetal alcohol spectrum disorders (FASD) to determine if global and/or focal abnormalities could be identified, and distinguish diagnostic subclassifications across the spectrum. The four study groups included: 1. FAS/Partial FAS; 2. Static Encephalopathy/Alcohol Exposed (SE/AE); 3. Neurobehavioral Disorder/Alcohol Exposed (ND/AE); and 4. healthy peers with no prenatal alcohol exposure. fMRI outcomes are reported here. The neuropsychological/psychiatric, MRI, and MRS outcomes are reported separately. fMRI was used to assess activation in seven brain regions during performance of N-back working memory tasks. Children across the full spectrum of FASD exhibited significant working memory deficits and altered activation patterns in brain regions that are known to be involved in working memory. These results demonstrate the potential research and diagnostic value of this noninvasive MR tool in the field of FASD.
AB - A comprehensive neuropsychological/psychiatric, MR imaging, (MRI), MR spectroscopy (MRS), and functional MRI (fMRI) assessment was administered to children with fetal alcohol spectrum disorders (FASD) to determine if global and/or focal abnormalities could be identified, and distinguish diagnostic subclassifications across the spectrum. The four study groups included: 1. FAS/Partial FAS; 2. Static Encephalopathy/Alcohol Exposed (SE/AE); 3. Neurobehavioral Disorder/Alcohol Exposed (ND/AE); and 4. healthy peers with no prenatal alcohol exposure. fMRI outcomes are reported here. The neuropsychological/psychiatric, MRI, and MRS outcomes are reported separately. fMRI was used to assess activation in seven brain regions during performance of N-back working memory tasks. Children across the full spectrum of FASD exhibited significant working memory deficits and altered activation patterns in brain regions that are known to be involved in working memory. These results demonstrate the potential research and diagnostic value of this noninvasive MR tool in the field of FASD.
KW - FASD 4-Digit Diagnostic Code
KW - Fetal alcohol spectrum disorder (FASD)
KW - Functional magnetic resonance imaging (fMRI)
KW - N-back
KW - Working memory
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U2 - 10.1007/s11689-009-9004-0
DO - 10.1007/s11689-009-9004-0
M3 - Article
C2 - 21547622
AN - SCOPUS:67349228354
SN - 1866-1947
VL - 1
SP - 61
EP - 80
JO - Journal of Neurodevelopmental Disorders
JF - Journal of Neurodevelopmental Disorders
IS - 1
ER -