Functional lateralization of the sensorimotor cortex in patients with schizophrenia: Effects of treatment with olanzapine

Alessandro Bertolino, Giuseppe Blasi, Grazia Caforio, Valeria Latorre, Mariapia De Candia, Valeria Rubino, Joseph H. Callicott, Venkata Mattay, Antonello Bellomo, Tommaso Scarabino, Daniel Weinberger, Marcello Nardini

Research output: Contribution to journalArticle

Abstract

Background Earlier cross-sectional studies with functional magnetic resonance imaging (fMRI) in treated patients with schizophrenia have reported abnormalities of cortical motor processing, including reduced lateralization of primary sensory motor cortex. The objective of the present longitudinal study was to evaluate whether such cortical abnormalities represent state or trait phenomena of the disorder. Methods Seventeen acutely ill, previously untreated patients were studied after 4 weeks and after 8 weeks of olanzapine therapy. Seventeen matched healthy subjects served as control subjects. All subjects underwent two fMRI scans 4 weeks apart during a visually paced motor task using a simple periodic block design. Functional magnetic resonance imaging data were analyzed in Statistical Parametric Mapping (SPM99). Region of interest analyses were used to determine a laterality quotient (an index of lateralization) of motor cortical regions. Results The fMRI data indicated that patients had reduced activation of the primary sensory motor cortex at 4 weeks but not at 8 weeks; however, the laterality quotient in the primary sensory motor cortex was reduced in patients at both time points. Conclusions These results suggest that some cortical abnormalities during motor processing represent state phenomena, whereas reduced functional lateralization of the primary sensory motor cortex represents an enduring trait of schizophrenia.

Original languageEnglish (US)
Pages (from-to)190-197
Number of pages8
JournalBiological Psychiatry
Volume56
Issue number3
DOIs
StatePublished - Aug 1 2004
Externally publishedYes

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olanzapine
Motor Cortex
Schizophrenia
Magnetic Resonance Imaging
Therapeutics
Longitudinal Studies
Healthy Volunteers
Cross-Sectional Studies
Sensorimotor Cortex

Keywords

  • fMRI
  • lateralization
  • motor processing
  • olanzapine
  • Schizophrenia
  • sensorimotor cortex

ASJC Scopus subject areas

  • Biological Psychiatry

Cite this

Functional lateralization of the sensorimotor cortex in patients with schizophrenia : Effects of treatment with olanzapine. / Bertolino, Alessandro; Blasi, Giuseppe; Caforio, Grazia; Latorre, Valeria; De Candia, Mariapia; Rubino, Valeria; Callicott, Joseph H.; Mattay, Venkata; Bellomo, Antonello; Scarabino, Tommaso; Weinberger, Daniel; Nardini, Marcello.

In: Biological Psychiatry, Vol. 56, No. 3, 01.08.2004, p. 190-197.

Research output: Contribution to journalArticle

Bertolino, A, Blasi, G, Caforio, G, Latorre, V, De Candia, M, Rubino, V, Callicott, JH, Mattay, V, Bellomo, A, Scarabino, T, Weinberger, D & Nardini, M 2004, 'Functional lateralization of the sensorimotor cortex in patients with schizophrenia: Effects of treatment with olanzapine', Biological Psychiatry, vol. 56, no. 3, pp. 190-197. https://doi.org/10.1016/j.biopsych.2004.04.009
Bertolino, Alessandro ; Blasi, Giuseppe ; Caforio, Grazia ; Latorre, Valeria ; De Candia, Mariapia ; Rubino, Valeria ; Callicott, Joseph H. ; Mattay, Venkata ; Bellomo, Antonello ; Scarabino, Tommaso ; Weinberger, Daniel ; Nardini, Marcello. / Functional lateralization of the sensorimotor cortex in patients with schizophrenia : Effects of treatment with olanzapine. In: Biological Psychiatry. 2004 ; Vol. 56, No. 3. pp. 190-197.
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