Functional implications of postural disequilibrium due to lead exposure

A. Bhattacharya, R. Shukla, K. N. Dietrich, J. Miller, A. Bagchee, R. L. Bornschein, C. Cox, T. Mitchell

Research output: Contribution to journalReview articlepeer-review

Abstract

Measurement of postural equilibrium has been employed as an indirect indicator of functional status of the nervous systems of 109 children (mean age: 5.8 ± 0.78 years) from the Cincinnati Lead Program Project. The geometric mean blood lead for the first five years of life (PbB05) was 11.9 ± 1.5 μg/dL. Postural sway associated with upright balance was noninvasively quantitated with a microprocessor-based force platform and four tasks performed for 30 sec each by the subjects. A covariate-adjusted multiple regression analysis showed statistically significant associations between PbB05 and the postural sway for the task requiring primarily vestibular and/or proprioceptive systems input, implying potential functional impairment. These findings raised several new issues which are addressed here: (1) A dynamic task has been developed to further test the effect of perturbing those afferents' functional capabilities. (2) A method has been developed to quantitate the stability boundary of each subject to better characterize the limits of functionally-safe postural sway. (3) There is a need to perform the postural sway in a shorter duration than 30 sec so that children younger than five years of age can be tested for early identification of Pb-induced functional impairment of postural equilibrium.

Original languageEnglish (US)
Pages (from-to)179-190
Number of pages12
JournalNeuroToxicology
Volume14
Issue number2-3
StatePublished - 1993
Externally publishedYes

Keywords

  • Children
  • Force Platform
  • Lead Exposure
  • Postural Balance
  • Stability Boundary

ASJC Scopus subject areas

  • Neuroscience(all)
  • Toxicology

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