Functional Imaging of the Human Lateral Geniculate Nucleus and Pulvinar

Sabine Kastner, Daniel H O'Connor, Miki M. Fukui, Hilda M. Fehd, Uwe Herwig, Mark A. Pinsk

Research output: Contribution to journalArticle

Abstract

In the human brain, little is known about the functional anatomy and response properties of subcortical nuclei containing visual maps such as the lateral geniculate nucleus (LGN) and the pulvinar. Using functional magnetic resonance imaging (fMRI) at 3 tesla (T), collective responses of neural populations in the LGN were measured as a function of stimulus contrast and flicker reversal rate and compared with those obtained in visual cortex. Flickering checkerboard stimuli presented in alternation to the right and left hemifields reliably activated the LGN. The peak of the LGN activation was found to be on average within ±2 mm of the anatomical location of the LGN, as identified on high-resolution structural images. In all visual areas except the middle temporal (MT), fMRI responses increased monotonically with stimulus contrast. In the LGN, the dynamic response range of the contrast function was larger and contrast gain was lower than in the cortex. Contrast sensitivity was lowest in the LGN and V1 and increased gradually in extrastriate cortex. In area MT, responses were saturated at 4% contrast. Response modulation by changes in flicker rate was similar in the LGN and V1 and occurred mainly in the frequency range between 0.5 and 7.5 Hz; in contrast, in extrastriate areas V4, V3A, and MT, responses were modulated mainly in the frequency range between 7.5 and 20 Hz. In the human pulvinar, no activations were obtained with the experimental designs used to probe response properties of the LGN. However, regions in the mediodorsal right and left pulvinar were found to be consistently activated by bilaterally presented flickering checkerboard stimuli, when subjects attended to the stimuli. Taken together, our results demonstrate that fMRI at 3 T can be used effectively to study thalamocortical circuits in the human brain.

Original languageEnglish (US)
Pages (from-to)438-448
Number of pages11
JournalJournal of Neurophysiology
Volume91
Issue number1
DOIs
StatePublished - Jan 2004
Externally publishedYes

Fingerprint

Pulvinar
Geniculate Bodies
Magnetic Resonance Imaging
Visual Cortex
Contrast Sensitivity
Brain
Anatomy
Research Design

ASJC Scopus subject areas

  • Physiology
  • Neuroscience(all)

Cite this

Functional Imaging of the Human Lateral Geniculate Nucleus and Pulvinar. / Kastner, Sabine; O'Connor, Daniel H; Fukui, Miki M.; Fehd, Hilda M.; Herwig, Uwe; Pinsk, Mark A.

In: Journal of Neurophysiology, Vol. 91, No. 1, 01.2004, p. 438-448.

Research output: Contribution to journalArticle

Kastner, Sabine ; O'Connor, Daniel H ; Fukui, Miki M. ; Fehd, Hilda M. ; Herwig, Uwe ; Pinsk, Mark A. / Functional Imaging of the Human Lateral Geniculate Nucleus and Pulvinar. In: Journal of Neurophysiology. 2004 ; Vol. 91, No. 1. pp. 438-448.
@article{3d0d7bbc7760487bb60c0c96e7e9ff82,
title = "Functional Imaging of the Human Lateral Geniculate Nucleus and Pulvinar",
abstract = "In the human brain, little is known about the functional anatomy and response properties of subcortical nuclei containing visual maps such as the lateral geniculate nucleus (LGN) and the pulvinar. Using functional magnetic resonance imaging (fMRI) at 3 tesla (T), collective responses of neural populations in the LGN were measured as a function of stimulus contrast and flicker reversal rate and compared with those obtained in visual cortex. Flickering checkerboard stimuli presented in alternation to the right and left hemifields reliably activated the LGN. The peak of the LGN activation was found to be on average within ±2 mm of the anatomical location of the LGN, as identified on high-resolution structural images. In all visual areas except the middle temporal (MT), fMRI responses increased monotonically with stimulus contrast. In the LGN, the dynamic response range of the contrast function was larger and contrast gain was lower than in the cortex. Contrast sensitivity was lowest in the LGN and V1 and increased gradually in extrastriate cortex. In area MT, responses were saturated at 4{\%} contrast. Response modulation by changes in flicker rate was similar in the LGN and V1 and occurred mainly in the frequency range between 0.5 and 7.5 Hz; in contrast, in extrastriate areas V4, V3A, and MT, responses were modulated mainly in the frequency range between 7.5 and 20 Hz. In the human pulvinar, no activations were obtained with the experimental designs used to probe response properties of the LGN. However, regions in the mediodorsal right and left pulvinar were found to be consistently activated by bilaterally presented flickering checkerboard stimuli, when subjects attended to the stimuli. Taken together, our results demonstrate that fMRI at 3 T can be used effectively to study thalamocortical circuits in the human brain.",
author = "Sabine Kastner and O'Connor, {Daniel H} and Fukui, {Miki M.} and Fehd, {Hilda M.} and Uwe Herwig and Pinsk, {Mark A.}",
year = "2004",
month = "1",
doi = "10.1152/jn.00553.2003",
language = "English (US)",
volume = "91",
pages = "438--448",
journal = "Journal of Neurophysiology",
issn = "0022-3077",
publisher = "American Physiological Society",
number = "1",

}

TY - JOUR

T1 - Functional Imaging of the Human Lateral Geniculate Nucleus and Pulvinar

AU - Kastner, Sabine

AU - O'Connor, Daniel H

AU - Fukui, Miki M.

AU - Fehd, Hilda M.

AU - Herwig, Uwe

AU - Pinsk, Mark A.

PY - 2004/1

Y1 - 2004/1

N2 - In the human brain, little is known about the functional anatomy and response properties of subcortical nuclei containing visual maps such as the lateral geniculate nucleus (LGN) and the pulvinar. Using functional magnetic resonance imaging (fMRI) at 3 tesla (T), collective responses of neural populations in the LGN were measured as a function of stimulus contrast and flicker reversal rate and compared with those obtained in visual cortex. Flickering checkerboard stimuli presented in alternation to the right and left hemifields reliably activated the LGN. The peak of the LGN activation was found to be on average within ±2 mm of the anatomical location of the LGN, as identified on high-resolution structural images. In all visual areas except the middle temporal (MT), fMRI responses increased monotonically with stimulus contrast. In the LGN, the dynamic response range of the contrast function was larger and contrast gain was lower than in the cortex. Contrast sensitivity was lowest in the LGN and V1 and increased gradually in extrastriate cortex. In area MT, responses were saturated at 4% contrast. Response modulation by changes in flicker rate was similar in the LGN and V1 and occurred mainly in the frequency range between 0.5 and 7.5 Hz; in contrast, in extrastriate areas V4, V3A, and MT, responses were modulated mainly in the frequency range between 7.5 and 20 Hz. In the human pulvinar, no activations were obtained with the experimental designs used to probe response properties of the LGN. However, regions in the mediodorsal right and left pulvinar were found to be consistently activated by bilaterally presented flickering checkerboard stimuli, when subjects attended to the stimuli. Taken together, our results demonstrate that fMRI at 3 T can be used effectively to study thalamocortical circuits in the human brain.

AB - In the human brain, little is known about the functional anatomy and response properties of subcortical nuclei containing visual maps such as the lateral geniculate nucleus (LGN) and the pulvinar. Using functional magnetic resonance imaging (fMRI) at 3 tesla (T), collective responses of neural populations in the LGN were measured as a function of stimulus contrast and flicker reversal rate and compared with those obtained in visual cortex. Flickering checkerboard stimuli presented in alternation to the right and left hemifields reliably activated the LGN. The peak of the LGN activation was found to be on average within ±2 mm of the anatomical location of the LGN, as identified on high-resolution structural images. In all visual areas except the middle temporal (MT), fMRI responses increased monotonically with stimulus contrast. In the LGN, the dynamic response range of the contrast function was larger and contrast gain was lower than in the cortex. Contrast sensitivity was lowest in the LGN and V1 and increased gradually in extrastriate cortex. In area MT, responses were saturated at 4% contrast. Response modulation by changes in flicker rate was similar in the LGN and V1 and occurred mainly in the frequency range between 0.5 and 7.5 Hz; in contrast, in extrastriate areas V4, V3A, and MT, responses were modulated mainly in the frequency range between 7.5 and 20 Hz. In the human pulvinar, no activations were obtained with the experimental designs used to probe response properties of the LGN. However, regions in the mediodorsal right and left pulvinar were found to be consistently activated by bilaterally presented flickering checkerboard stimuli, when subjects attended to the stimuli. Taken together, our results demonstrate that fMRI at 3 T can be used effectively to study thalamocortical circuits in the human brain.

UR - http://www.scopus.com/inward/record.url?scp=0347717976&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0347717976&partnerID=8YFLogxK

U2 - 10.1152/jn.00553.2003

DO - 10.1152/jn.00553.2003

M3 - Article

C2 - 13679404

AN - SCOPUS:0347717976

VL - 91

SP - 438

EP - 448

JO - Journal of Neurophysiology

JF - Journal of Neurophysiology

SN - 0022-3077

IS - 1

ER -