Functional Imaging of Cognitive Control During Acute Alcohol Intoxication

Beth M. Anderson, Michael C. Stevens, Shashwath A. Meda, Kathryn Jordan, Vince D. Calhoun, Godfrey D. Pearlson

    Research output: Contribution to journalArticle

    Abstract

    Background: The anterior cingulate and several other prefrontal and parietal brain regions are implicated in error processing and cognitive control. The effects of different doses of alcohol on activity within these brain regions during a functional magnetic resonance imaging (fMRI) task where errors are frequently committed have not been fully explored.Methods: This study examined the impact of a placebo [breath alcohol concentration (BrAC) = 0.00%], moderate (BrAC = 0.05%), and high (BrAC = 0.10%) doses of alcohol on brain hemodynamic activity during a functional MRI (fMRI) Go/No-Go task in 38 healthy volunteers.Results: Alcohol increased reaction time and false alarm errors in a dose-dependent manner. fMRI analyses showed alcohol decreased activity in anterior cingulate, lateral prefrontal cortex, insula, and parietal lobe regions during false alarm responses to No-Go stimuli.Conclusions: These findings indicate that brain regions implicated in error processing are affected by alcohol and might provide a neural basis for alcohol's effects on behavioral performance.

    Original languageEnglish (US)
    Pages (from-to)156-165
    Number of pages10
    JournalAlcoholism: Clinical and Experimental Research
    Volume35
    Issue number1
    DOIs
    StatePublished - Jan 2011

    Keywords

    • Alcohol
    • Anterior Cingulate
    • Error Monitoring
    • Functional Imaging
    • Go/No-Go

    ASJC Scopus subject areas

    • Medicine (miscellaneous)
    • Toxicology
    • Psychiatry and Mental health

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