Functional imaging in small animals using tomographic digital subtraction angiography

Cristian T. Badea, Laurence W. Hedlund, Ming De Lin, Julie F. Boslego, G. Allan Johnson

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

We propose the use of Tomographic Digital Subtraction Angiography (TDSA) for functional imaging in small animals. TDSA combines the advantages of high temporal resolution of digital subtraction angiography (DSA) and high spatial resolution of micro-computed tomography (CT). TDSA augments projection imaging methods such as DSA by providing three-dimensional information using tomosynthesis or CT reconstruction algorithms. Thus, four-dimensional (4D) datasets with a temporal resolution on the order of 100 ms and spatial resolution ranging from 100 microns to 1 mm, depending on the scanning angle, can be obtained. The approach is based on the novel paradigm that the same time density curves can be reproduced in a number of consecutive injections of microL volumes of contrast at a series of different angles of rotation.

Original languageEnglish (US)
Title of host publication2006 3rd IEEE International Symposium on Biomedical Imaging
Subtitle of host publicationFrom Nano to Macro - Proceedings
Pages1208-1211
Number of pages4
StatePublished - Nov 17 2006
Event2006 3rd IEEE International Symposium on Biomedical Imaging: From Nano to Macro - Arlington, VA, United States
Duration: Apr 6 2006Apr 9 2006

Publication series

Name2006 3rd IEEE International Symposium on Biomedical Imaging: From Nano to Macro - Proceedings
Volume2006

Other

Other2006 3rd IEEE International Symposium on Biomedical Imaging: From Nano to Macro
CountryUnited States
CityArlington, VA
Period4/6/064/9/06

ASJC Scopus subject areas

  • Engineering(all)

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