Functional identification of neuroprotective molecules

Cheng Dai, Dong Liang, Huiwu Li, Masayuki Sasaki, Ted M. Dawson, Valina L. Dawson

Research output: Contribution to journalArticlepeer-review

Abstract

The central nervous system has the capacity to activate profound neuroprotection following sub-lethal stress in a process termed preconditioning. To gain insight into this potent survival response we developed a functional cloning strategy that identified 31 putative neuroprotective genes of which 28 were confirmed to provide protection against oxygen-glucose deprivation (OGD) or excitotoxic exposure to N-methyl-D-aspartate (NMDA) in primary rat cortical neurons. These results reveal that the brain possesses a wide and diverse repertoire of neuroprotective genes. Further characterization of these and other protective signals could provide new treatment opportunities for neurological injury from ischemia or neurodegenerative disease.

Original languageEnglish (US)
Article numbere15008
JournalPloS one
Volume5
Issue number11
DOIs
StatePublished - Nov 24 2010

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)
  • General

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