Functional hyposplenia after splenic irradiation for Hodgkin's disease

C. N. Coleman, I. R. McDougall, M. O. Dailey, P. Ager, S. Bush, H. S. Kaplan

Research output: Contribution to journalArticle

Abstract

We previously reported a patient who developed fulminant pneumococcal sepsis 12 years after successful treatment for Hodgkin's disease, which included splenic irradiation. We have since evaluated splenic size and function in 25 patients who had received splenic irradiation 5 to 16 years previously either for Hodgkin's disease (n = 19) or non-Hodgkin's lymphoma (n = 6). Mean maximum splenic diameter as measured on a (99m)Tc-sulfur colloid liverspleen scan was 6.2 cm in the irradiated group and 9.7 cm in a control group (p <0.001). The mean percentage of erythrocytes containing pits when observed with interference phase microscopy was 13.0% in the irradiated group, which was significantly different (p <0.001) from the levels found in each of the control groups: normal subjects, 0.9%; unstaged and untreated lymphoma patients, 0.6%; and patients after splenectomy, 33.7%. Patients who have had splenic irradiation should be considered at risk of developing overwhelming pneumococcal sepsis.

Original languageEnglish (US)
Pages (from-to)44-47
Number of pages4
JournalAnnals of Internal Medicine
Volume96
Issue number1
StatePublished - 1982
Externally publishedYes

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Hodgkin Disease
Sepsis
Technetium Tc 99m Sulfur Colloid
Interference Microscopy
Control Groups
Splenectomy
Non-Hodgkin's Lymphoma
Lymphoma
Erythrocytes
Therapeutics

ASJC Scopus subject areas

  • Medicine(all)

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Coleman, C. N., McDougall, I. R., Dailey, M. O., Ager, P., Bush, S., & Kaplan, H. S. (1982). Functional hyposplenia after splenic irradiation for Hodgkin's disease. Annals of Internal Medicine, 96(1), 44-47.

Functional hyposplenia after splenic irradiation for Hodgkin's disease. / Coleman, C. N.; McDougall, I. R.; Dailey, M. O.; Ager, P.; Bush, S.; Kaplan, H. S.

In: Annals of Internal Medicine, Vol. 96, No. 1, 1982, p. 44-47.

Research output: Contribution to journalArticle

Coleman, CN, McDougall, IR, Dailey, MO, Ager, P, Bush, S & Kaplan, HS 1982, 'Functional hyposplenia after splenic irradiation for Hodgkin's disease', Annals of Internal Medicine, vol. 96, no. 1, pp. 44-47.
Coleman CN, McDougall IR, Dailey MO, Ager P, Bush S, Kaplan HS. Functional hyposplenia after splenic irradiation for Hodgkin's disease. Annals of Internal Medicine. 1982;96(1):44-47.
Coleman, C. N. ; McDougall, I. R. ; Dailey, M. O. ; Ager, P. ; Bush, S. ; Kaplan, H. S. / Functional hyposplenia after splenic irradiation for Hodgkin's disease. In: Annals of Internal Medicine. 1982 ; Vol. 96, No. 1. pp. 44-47.
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