Functional hierarchy underlies preferential connectivity disturbances in schizophrenia

Genevieve J. Yang, John D. Murray, Xiao Jing Wang, David C. Glahn, Godfrey D. Pearlson, Grega Repovs, John H. Krystal, Alan Anticevic

Research output: Contribution to journalArticle

Abstract

Schizophrenia may involve an elevated excitation/inhibition (E/I) ratio in cortical microcircuits. It remains unknown how this regulatory disturbance maps onto neuroimaging findings. To address this issue, we implemented E/I perturbations within a neural model of large-scale functional connectivity, which predicted hyperconnectivity following E/I elevation. To test predictions, we examined restingstate functional MRI in 161 schizophrenia patients and 164 healthy subjects. As predicted, patients exhibited elevated functional connectivity that correlated with symptom levels, and was most prominent in association cortices, such as the fronto-parietal control network. This pattern was absent in patients with bipolar disorder (n = 73). To account for the pattern observed in schizophrenia, we integrated neurobiologically plausible, hierarchical differences in association vs. sensory recurrent neuronal dynamics into our model. This in silico architecture revealed preferential vulnerability of association networks to E/I imbalance, which we verified empirically. Reported effects implicate widespread microcircuit E/I imbalance as a parsimonious mechanism for emergent inhomogeneous dysconnectivity in schizophrenia.

Original languageEnglish (US)
Pages (from-to)E219-E228
JournalProceedings of the National Academy of Sciences of the United States of America
Volume113
Issue number2
DOIs
StatePublished - Jan 12 2016
Externally publishedYes

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Schizophrenia
Bipolar Disorder
Neuroimaging
Computer Simulation
Healthy Volunteers
Magnetic Resonance Imaging
Inhibition (Psychology)

Keywords

  • Computational modeling
  • Functional connectivity
  • Schizophrenia

ASJC Scopus subject areas

  • General

Cite this

Functional hierarchy underlies preferential connectivity disturbances in schizophrenia. / Yang, Genevieve J.; Murray, John D.; Wang, Xiao Jing; Glahn, David C.; Pearlson, Godfrey D.; Repovs, Grega; Krystal, John H.; Anticevic, Alan.

In: Proceedings of the National Academy of Sciences of the United States of America, Vol. 113, No. 2, 12.01.2016, p. E219-E228.

Research output: Contribution to journalArticle

Yang, GJ, Murray, JD, Wang, XJ, Glahn, DC, Pearlson, GD, Repovs, G, Krystal, JH & Anticevic, A 2016, 'Functional hierarchy underlies preferential connectivity disturbances in schizophrenia', Proceedings of the National Academy of Sciences of the United States of America, vol. 113, no. 2, pp. E219-E228. https://doi.org/10.1073/pnas.1508436113
Yang, Genevieve J. ; Murray, John D. ; Wang, Xiao Jing ; Glahn, David C. ; Pearlson, Godfrey D. ; Repovs, Grega ; Krystal, John H. ; Anticevic, Alan. / Functional hierarchy underlies preferential connectivity disturbances in schizophrenia. In: Proceedings of the National Academy of Sciences of the United States of America. 2016 ; Vol. 113, No. 2. pp. E219-E228.
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