Functional diversity of SDF-1 splicing variants

Miroslaw Janowski

Research output: Contribution to journalArticle

Abstract

SDF-1 is ubiquitously expressed in vertebrate tissues in a constitutive manner. It performs an essential role in cell migration and proliferation as well as participates in tissue-specific physiological processes such as neuromodulation. It is also involved in many pathological processes including: HIV infection, metastatic malignancy, chronic inflammatory disorders and benign proliferative diseases. SDF-1 is mostly regulated at the splicing, and not transcriptional level. Different splicing variants share agonist potency to their cognate receptor, CXCR4, but are characterized by distinct properties. SDF-1α is the predominant isoform found in all organs, but undergoes rapid proteolysis in blood. SDF-1β is more resistant to blood-dependent degradation, stimulates angiogenesis and is present in highly vascularized organs such as: the liver, spleen and kidneys. In contrast, SDF-1γ is located in very active, less vascularized organs susceptible to infarction such as the heart and the brain. The understanding of the functional diversity of the different splicing variants will help in developing therapeutic strategies.

Original languageEnglish (US)
Pages (from-to)243-249
Number of pages7
JournalCell Adhesion and Migration
Volume3
Issue number3
Publication statusPublished - Jul 2009
Externally publishedYes

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Keywords

  • Cell based-therapy
  • CXCR4
  • CXCR7
  • Isoform
  • SDF-1
  • Splicing variant

ASJC Scopus subject areas

  • Cell Biology
  • Cellular and Molecular Neuroscience

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