Functional diversity of protein C-termini: More than zipcoding?

Jean Ju Chung, Sojin Shikano, Yoshiro Hanyu, Min Li

Research output: Contribution to journalArticle

Abstract

The carboxylated (C)-terminus of proteins, which includes the single terminal α-carboxyl group and preceding residues, is uniquely positioned to serve as a recognition signature for a variety of cell-biological processes, including protein targeting, subcellular anchoring and the static and dynamic formation of macromolecular complexes. The terminal sequence motifs can be processed by posttranslational modifications, thereby providing a means to increase sequence diversity and to regulate interactions. Several classes of protein domains have been identified that are either designed for or are capable of interacting with protein C-termini - these include PDZ and TPR domains. The interactions between these protein domains and various terminal epitopes play an important role in specifying cell-biological functions. The combination of diversity and the plasticity of the chemistry of C-termini provides mechanisms for spatial and temporal specificity that are exploited by a variety of biological processes, ranging from specifying prokaryotic protein degradation to nucleating mammalian neuronal signaling complexes. Understanding the diverse functions of protein C-termini might also provide an important indexing criterion for functional proteomics.

Original languageEnglish (US)
Pages (from-to)146-150
Number of pages5
JournalTrends in Cell Biology
Volume12
Issue number3
DOIs
StatePublished - Mar 1 2002

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Protein C
Biological Phenomena
Protein Interaction Domains and Motifs
PDZ Domains
Macromolecular Substances
Protein Transport
Post Translational Protein Processing
Proteomics
Proteolysis
Epitopes

ASJC Scopus subject areas

  • Cell Biology

Cite this

Functional diversity of protein C-termini : More than zipcoding? / Chung, Jean Ju; Shikano, Sojin; Hanyu, Yoshiro; Li, Min.

In: Trends in Cell Biology, Vol. 12, No. 3, 01.03.2002, p. 146-150.

Research output: Contribution to journalArticle

Chung, Jean Ju ; Shikano, Sojin ; Hanyu, Yoshiro ; Li, Min. / Functional diversity of protein C-termini : More than zipcoding?. In: Trends in Cell Biology. 2002 ; Vol. 12, No. 3. pp. 146-150.
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