TY - JOUR
T1 - Functional decline in peripheral arterial disease
T2 - Associations with the ankle brachial index and leg symptoms
AU - McDermott, Mary McGrae
AU - Liu, Kiang
AU - Greenland, Philip
AU - Guralnik, Jack M.
AU - Criqui, Michael H.
AU - Chan, Cheeling
AU - Pearce, William H.
AU - Schneider, Joseph R.
AU - Ferrucci, Luigi
AU - Celic, Lillian
AU - Taylor, Lloyd M.
AU - Vonesh, Ed
AU - Martin, Gary J.
AU - Clark, Elizabeth
PY - 2004/7/28
Y1 - 2004/7/28
N2 - Context: Among individuals with lower-extremity peripheral arterial disease (PAD), specific leg symptoms and the ankle brachial index (ABI) are cross-sectionally related to the degree of functional impairment. However, relations between these clinical characteristics and objectively measured functional decline are unknown. Objective: To define whether PAD, ABI, and specific leg symptoms predict functional decline at 2-year follow-up. Design, Setting, and Participants: Prospective cohort study among 676 consecutively identified individuals (aged ≥55 years) with and without PAD (n=417 and n=259, respectively), with baseline functional assessments occurring between October 1, 1998, and January 31, 2000, and follow-up assessments scheduled 1 and 2 years thereafter. PAD was defined as ABI less than 0.90, and participants with PAD were categorized at baseline into 1 of 5 mutually exclusive symptom groups. Main Outcome Measures: Mean annual changes in 6-minute walk performance and in usual-paced and fast-paced 4-m walking velocity, adjusted for age, sex, race, prior-year functioning, comorbid diseases, body mass index, pack-years of cigarette smoking, and patterns of missing data. Results: Lower baseline ABI values were associated with greater mean (95% confidence interval) annual decline in 6-minute walk performance (-73.0 [-142 to -4.2] ft for ABI
AB - Context: Among individuals with lower-extremity peripheral arterial disease (PAD), specific leg symptoms and the ankle brachial index (ABI) are cross-sectionally related to the degree of functional impairment. However, relations between these clinical characteristics and objectively measured functional decline are unknown. Objective: To define whether PAD, ABI, and specific leg symptoms predict functional decline at 2-year follow-up. Design, Setting, and Participants: Prospective cohort study among 676 consecutively identified individuals (aged ≥55 years) with and without PAD (n=417 and n=259, respectively), with baseline functional assessments occurring between October 1, 1998, and January 31, 2000, and follow-up assessments scheduled 1 and 2 years thereafter. PAD was defined as ABI less than 0.90, and participants with PAD were categorized at baseline into 1 of 5 mutually exclusive symptom groups. Main Outcome Measures: Mean annual changes in 6-minute walk performance and in usual-paced and fast-paced 4-m walking velocity, adjusted for age, sex, race, prior-year functioning, comorbid diseases, body mass index, pack-years of cigarette smoking, and patterns of missing data. Results: Lower baseline ABI values were associated with greater mean (95% confidence interval) annual decline in 6-minute walk performance (-73.0 [-142 to -4.2] ft for ABI
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U2 - 10.1001/jama.292.4.453
DO - 10.1001/jama.292.4.453
M3 - Article
C2 - 15280343
AN - SCOPUS:3242749825
SN - 0098-7484
VL - 292
SP - 453
EP - 461
JO - Journal of the American Medical Association
JF - Journal of the American Medical Association
IS - 4
ER -