Functional decline in patients with and without peripheral arterial disease: Predictive value of annual changes in levels of C-reactive protein and D-dimer

Mary M. McDermott, Kiang Liu, Jack M. Guralnik, Luigi Ferrucci, David Green, Philip Greenland, Lu Tian, Michael H. Criqui, Carol Lo, Nader Rifai, Paul M. Ridker, Jane Zheng, William Pearce

Research output: Contribution to journalArticle

Abstract

Background. Inflammation may be a potential mechanism of aging-related functional decline. We determined whether greater annual increases in levels of high sensitivity C-reactive protein (hsCRP) and D-dimer predicted greater decline in functioning among persons with and without lower extremity peripheral arterial disease (PAD). Methods. We prospectively studied 296 men and women with PAD and 191 without PAD. Objective measures of functioning, hsCRP, and D-dimer were obtained at baseline and annually for 3 years (mean follow-up = 36.3 ± 6.4 months). Results. Among PAD participants, greater annual increases in hsCRP were associated with greater annual declines in 6-minute walk performance (-2.63 ft/mg/L, p = .039) but not in other functional outcomes. Higher prior year absolute hsCRP levels were associated with greater declines in 6-minute walk (-2.93 ft/mg/L, p = .022), summary performance score (-0.038/mg/L, p = .017), and rapid paced 4-meter walk (-0.29 cm/s/mg/L, p = .026) during the subsequent year. Among participants without PAD, greater annual increases in hsCRP were associated with greater annual declines in 6-minute walk (-7.47 ft/mg/L, p = .002), usual-pace 4-meter walk (-0.33 cm/s/mg/L, p <.001), fast paced 4-meter walk (-0.56 cm/s/mg/L, p = .003), and the summary performance score (-0.029 mg/L, p <.001). There were no consistent associations between D-dimer levels and functional decline. Conclusion. These findings suggest that inflammation may play a role in functional decline in persons with and without PAD.

Original languageEnglish (US)
Pages (from-to)374-379
Number of pages6
JournalJournals of Gerontology - Series A Biological Sciences and Medical Sciences
Volume61
Issue number4
StatePublished - Apr 2006
Externally publishedYes

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Peripheral Arterial Disease
C-Reactive Protein
Inflammation
fibrin fragment D
Lower Extremity

ASJC Scopus subject areas

  • Aging

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Functional decline in patients with and without peripheral arterial disease : Predictive value of annual changes in levels of C-reactive protein and D-dimer. / McDermott, Mary M.; Liu, Kiang; Guralnik, Jack M.; Ferrucci, Luigi; Green, David; Greenland, Philip; Tian, Lu; Criqui, Michael H.; Lo, Carol; Rifai, Nader; Ridker, Paul M.; Zheng, Jane; Pearce, William.

In: Journals of Gerontology - Series A Biological Sciences and Medical Sciences, Vol. 61, No. 4, 04.2006, p. 374-379.

Research output: Contribution to journalArticle

McDermott, MM, Liu, K, Guralnik, JM, Ferrucci, L, Green, D, Greenland, P, Tian, L, Criqui, MH, Lo, C, Rifai, N, Ridker, PM, Zheng, J & Pearce, W 2006, 'Functional decline in patients with and without peripheral arterial disease: Predictive value of annual changes in levels of C-reactive protein and D-dimer', Journals of Gerontology - Series A Biological Sciences and Medical Sciences, vol. 61, no. 4, pp. 374-379.
McDermott, Mary M. ; Liu, Kiang ; Guralnik, Jack M. ; Ferrucci, Luigi ; Green, David ; Greenland, Philip ; Tian, Lu ; Criqui, Michael H. ; Lo, Carol ; Rifai, Nader ; Ridker, Paul M. ; Zheng, Jane ; Pearce, William. / Functional decline in patients with and without peripheral arterial disease : Predictive value of annual changes in levels of C-reactive protein and D-dimer. In: Journals of Gerontology - Series A Biological Sciences and Medical Sciences. 2006 ; Vol. 61, No. 4. pp. 374-379.
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T2 - Predictive value of annual changes in levels of C-reactive protein and D-dimer

AU - McDermott, Mary M.

AU - Liu, Kiang

AU - Guralnik, Jack M.

AU - Ferrucci, Luigi

AU - Green, David

AU - Greenland, Philip

AU - Tian, Lu

AU - Criqui, Michael H.

AU - Lo, Carol

AU - Rifai, Nader

AU - Ridker, Paul M.

AU - Zheng, Jane

AU - Pearce, William

PY - 2006/4

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N2 - Background. Inflammation may be a potential mechanism of aging-related functional decline. We determined whether greater annual increases in levels of high sensitivity C-reactive protein (hsCRP) and D-dimer predicted greater decline in functioning among persons with and without lower extremity peripheral arterial disease (PAD). Methods. We prospectively studied 296 men and women with PAD and 191 without PAD. Objective measures of functioning, hsCRP, and D-dimer were obtained at baseline and annually for 3 years (mean follow-up = 36.3 ± 6.4 months). Results. Among PAD participants, greater annual increases in hsCRP were associated with greater annual declines in 6-minute walk performance (-2.63 ft/mg/L, p = .039) but not in other functional outcomes. Higher prior year absolute hsCRP levels were associated with greater declines in 6-minute walk (-2.93 ft/mg/L, p = .022), summary performance score (-0.038/mg/L, p = .017), and rapid paced 4-meter walk (-0.29 cm/s/mg/L, p = .026) during the subsequent year. Among participants without PAD, greater annual increases in hsCRP were associated with greater annual declines in 6-minute walk (-7.47 ft/mg/L, p = .002), usual-pace 4-meter walk (-0.33 cm/s/mg/L, p <.001), fast paced 4-meter walk (-0.56 cm/s/mg/L, p = .003), and the summary performance score (-0.029 mg/L, p <.001). There were no consistent associations between D-dimer levels and functional decline. Conclusion. These findings suggest that inflammation may play a role in functional decline in persons with and without PAD.

AB - Background. Inflammation may be a potential mechanism of aging-related functional decline. We determined whether greater annual increases in levels of high sensitivity C-reactive protein (hsCRP) and D-dimer predicted greater decline in functioning among persons with and without lower extremity peripheral arterial disease (PAD). Methods. We prospectively studied 296 men and women with PAD and 191 without PAD. Objective measures of functioning, hsCRP, and D-dimer were obtained at baseline and annually for 3 years (mean follow-up = 36.3 ± 6.4 months). Results. Among PAD participants, greater annual increases in hsCRP were associated with greater annual declines in 6-minute walk performance (-2.63 ft/mg/L, p = .039) but not in other functional outcomes. Higher prior year absolute hsCRP levels were associated with greater declines in 6-minute walk (-2.93 ft/mg/L, p = .022), summary performance score (-0.038/mg/L, p = .017), and rapid paced 4-meter walk (-0.29 cm/s/mg/L, p = .026) during the subsequent year. Among participants without PAD, greater annual increases in hsCRP were associated with greater annual declines in 6-minute walk (-7.47 ft/mg/L, p = .002), usual-pace 4-meter walk (-0.33 cm/s/mg/L, p <.001), fast paced 4-meter walk (-0.56 cm/s/mg/L, p = .003), and the summary performance score (-0.029 mg/L, p <.001). There were no consistent associations between D-dimer levels and functional decline. Conclusion. These findings suggest that inflammation may play a role in functional decline in persons with and without PAD.

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