Functional connectivity in the developing brain: A longitudinal study from 4 to 9months of age

E. Damaraju, A. Caprihan, J. R. Lowe, E. A. Allen, Vince Daniel Calhoun, J. P. Phillips

Research output: Contribution to journalArticle

Abstract

We characterize the development of intrinsic connectivity networks (ICNs) from 4 to 9. months of age with resting state magnetic resonance imaging performed on sleeping infants without sedative medication. Data is analyzed with independent component analysis (ICA). Using both low (30 components) and high (100 components) ICA model order decompositions, we find that the functional network connectivity (FNC) map is largely similar at both 4 and 9. months. However at 9. months the connectivity strength decreases within local networks and increases between more distant networks. The connectivity within the default-mode network, which contains both local and more distant nodes, also increases in strength with age. The low frequency power spectrum increases with age only in the posterior cingulate cortex and posterior default mode network. These findings are consistent with a general developmental pattern of increasing longer distance functional connectivity over the first year of life and raise questions regarding the developmental importance of the posterior cingulate at this age.

Original languageEnglish (US)
Pages (from-to)169-180
Number of pages12
JournalNeuroImage
Volume84
DOIs
StatePublished - Jan 1 2014
Externally publishedYes

Fingerprint

Gyrus Cinguli
Longitudinal Studies
Brain
Hypnotics and Sedatives
Magnetic Resonance Imaging

Keywords

  • Functional network connectivity
  • High model order analysis
  • Independent component analysis
  • Intrinsic connectivity networks
  • Longitudinal study in infants

ASJC Scopus subject areas

  • Cognitive Neuroscience
  • Neurology
  • Medicine(all)

Cite this

Functional connectivity in the developing brain : A longitudinal study from 4 to 9months of age. / Damaraju, E.; Caprihan, A.; Lowe, J. R.; Allen, E. A.; Calhoun, Vince Daniel; Phillips, J. P.

In: NeuroImage, Vol. 84, 01.01.2014, p. 169-180.

Research output: Contribution to journalArticle

Damaraju, E. ; Caprihan, A. ; Lowe, J. R. ; Allen, E. A. ; Calhoun, Vince Daniel ; Phillips, J. P. / Functional connectivity in the developing brain : A longitudinal study from 4 to 9months of age. In: NeuroImage. 2014 ; Vol. 84. pp. 169-180.
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