Functional connectivity during affective mentalizing in criminal offenders with psychotic disorders: Associations with clinical symptoms

Carla L. Harenski, Vince Daniel Calhoun, Juan R. Bustillo, Brian W. Haas, Jean Decety, Keith A. Harenski, Michael F. Caldwell, Gregory J. Van Rybroek, Michael Koenigs, David M. Thornton, Kent A. Kiehl

Research output: Contribution to journalArticle

Abstract

Psychotic disorders are associated with neurobehavioral impairments in mental state attribution (mentalizing). These impairments are most severe in psychotic patients with elevated symptom levels, particularly negative and cognitive symptoms. There have been few studies of functional connectivity related to mentalizing in psychotic disorders and associations with symptoms. We conducted a functional MRI study of affective mentalizing in individuals with psychotic disorders and varying symptom levels (positive, negative, cognitive). Participants were drawn from an adjudicated inpatient forensic psychiatric population (criminal offenders). Functional MRI scans were acquired using a 32-channel ultra-fast multiband imaging sequence. Mentalizing task performance and functional connectivity were assessed in psychotic criminal offenders (n = 46) and nonpsychotic offenders (n = 41). Temporal coherent brain networks were estimated with group independent component analysis (ICA). Relative to nonpsychotic offenders, psychotic offenders showed impaired task performance and reduced activation in a component comprising the dorsomedial prefrontal cortex, superior temporal gyrus, and ventrolateral prefrontal cortex. Positive and cognitive symptoms were inversely correlated with component activity and task performance. The results are discussed with reference to potential mechanisms underlying impaired social cognition in psychotic disorders and across symptom types.

Original languageEnglish (US)
Pages (from-to)91-99
Number of pages9
JournalPsychiatry Research - Neuroimaging
Volume271
DOIs
StatePublished - Jan 30 2018
Externally publishedYes

Keywords

  • fMRI
  • Psychosis
  • Social cognition

ASJC Scopus subject areas

  • Neuroscience (miscellaneous)
  • Radiology Nuclear Medicine and imaging
  • Psychiatry and Mental health

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    Harenski, C. L., Calhoun, V. D., Bustillo, J. R., Haas, B. W., Decety, J., Harenski, K. A., Caldwell, M. F., Van Rybroek, G. J., Koenigs, M., Thornton, D. M., & Kiehl, K. A. (2018). Functional connectivity during affective mentalizing in criminal offenders with psychotic disorders: Associations with clinical symptoms. Psychiatry Research - Neuroimaging, 271, 91-99. https://doi.org/10.1016/j.pscychresns.2017.11.003