Functional antagonism of airway constriction in the canine lung periphery

K. S. Lindeman, C. A. Hirshman, A. N. Freed

Research output: Contribution to journalArticle

Abstract

We studied the ability of a β-adrenergic agonist (albuterol) to attenuate calcium chelator- and acetylcholine-induced airway constriction in the lung periphery of anesthetized mongrel and Basenji-Greyhound (BG) dogs. A wedged bronchoscope technique was used to measure collateral system resistance before and after challenges with aerosolized Na2EDTA and acetylcholine. Time course of the response to Na2EDTA differed significantly between mongrel and BG dogs. Peak response to challenge with 4% Na2EDTA occurred within 2 min for mongrel dogs and at 5 min for BG dogs. Albuterol (1 μg/kg iv) significantly attenuated Na2EDTA-induced bronchoconstriction in both groups of animals (P < 0.01, each group). Albuterol (1 μg/kg iv) significantly attenuated acetylcholine-induced bronchoconstriction in mongrel (P < 0.01) but not in BG dogs. We conclude that a qualitative difference exists in the mechanism of Na2EDTA-induced constriction in the lung periphery of BG compared with mongrel dogs. In addition, the lung periphery of BG dogs demonstrates reduced β-adrenergic sensitivity with respect to a cholinergic challenge compared with mongrels, suggesting enhanced cholinergic inhibition of the β-adrenergic system.

Original languageEnglish (US)
Pages (from-to)1848-1855
Number of pages8
JournalJournal of applied physiology
Volume71
Issue number5
StatePublished - Jan 1 1991

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Keywords

  • albuterol
  • bronchoconstriction
  • collateral resistance
  • ethylenediaminetetraacetic acid
  • functional antagonism
  • β-adrenergic agonists

ASJC Scopus subject areas

  • Physiology
  • Physiology (medical)

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