TY - JOUR
T1 - Functional and regulatory characteristics of eukaryotic type II DNA topoisomerase
AU - Bakshi, Rahul P.
AU - Galande, Sanjeev
AU - Muniyappa, K.
N1 - Funding Information:
We thank the reviewer for useful com ments. This work was supported by the Department of Biotechnology, New Delhi.
PY - 2001
Y1 - 2001
N2 - DNA topoisomerases are ubiquitous nuclear enzymes that govern the topological interconversions of DNA by transiently breaking/rejoining the phosphodiester backbone of one (type I) or both (type II) strands of the double helix. Consistent with these functions, topoisomerases play key roles in many aspects of DNA metabolism. Type II DNA topoisomerase (topo II) is vital for various nuclear processes, including DNA replication, chromosome segregation, and maintenance of chromosome structure. Topo II expression is regulated at multiple stages, including transcriptional, posttranscriptional, and posttranslational levels, by a multitude of signaling factors. Topo II is also the cellular target for a variety of clinically relevant anti-tumor drugs. Despite significant progress in our understanding of the role of topo II in diverse nuclear processes, several important aspects of topo II function, expression, and regulation are poorly understood. We have focused this review specifically on eukaryotic DNA topoisomerase II, with an emphasis on functional and regulatory characteristics.
AB - DNA topoisomerases are ubiquitous nuclear enzymes that govern the topological interconversions of DNA by transiently breaking/rejoining the phosphodiester backbone of one (type I) or both (type II) strands of the double helix. Consistent with these functions, topoisomerases play key roles in many aspects of DNA metabolism. Type II DNA topoisomerase (topo II) is vital for various nuclear processes, including DNA replication, chromosome segregation, and maintenance of chromosome structure. Topo II expression is regulated at multiple stages, including transcriptional, posttranscriptional, and posttranslational levels, by a multitude of signaling factors. Topo II is also the cellular target for a variety of clinically relevant anti-tumor drugs. Despite significant progress in our understanding of the role of topo II in diverse nuclear processes, several important aspects of topo II function, expression, and regulation are poorly understood. We have focused this review specifically on eukaryotic DNA topoisomerase II, with an emphasis on functional and regulatory characteristics.
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U2 - 10.1080/20014091074165
DO - 10.1080/20014091074165
M3 - Review article
C2 - 11256504
AN - SCOPUS:0035092216
SN - 1040-9238
VL - 36
SP - 1
EP - 37
JO - Critical reviews in biochemistry and molecular biology
JF - Critical reviews in biochemistry and molecular biology
IS - 1
ER -