Functional and morphologic changes after lung allografting in baboons

R. R. Baker, P. Sabanayagam, C. K. Zarins, A. E. James, G. M. Hutchins, J. M. Byers IIIrd, T. K. Katarajan, J. M. Lee

Research output: Contribution to journalArticlepeer-review

Abstract

Nine baboons received left lung allografts. Serial biopsies were obtained in two baboons and serial roentgenograms of the chest and inhalation lung scintiscans were obtained in the remaining seven. All nine demonstrated roentgenographically an increasing consolidation of the allograft and also a progressive decline in alveolar volumes of the allograft for the first six to eight days after operation. In three baboons clearing of the allograft was demonstrated roentgenographically, and there was a return of alveolar volumes in the allograft to preoperative control values by 15 days after operation. In three baboons, consolidation failed to clear, and relative alveolar volumes in the allograft remained depressed. The serial biopsies and the findings at autopsy revealed morphologic evidence of rejection in three of nine baboons. The initial increasing consolidation of the allograft on the roentgenograms of the chest and the associated decline in ventilatory function were attributed to the operative procedures, primarily interruption of the lymphatic drainage. When lymphatic regeneration began to occur, three baboons had a clearing of the consolidation, roentgenographically, and the serial inhalation scintiscans detected a similar improvement in ventilatory function.

Original languageEnglish (US)
Pages (from-to)650-654
Number of pages5
JournalSurgery Gynecology and Obstetrics
Volume137
Issue number4
StatePublished - Dec 1 1973

ASJC Scopus subject areas

  • Surgery
  • Obstetrics and Gynecology

Fingerprint Dive into the research topics of 'Functional and morphologic changes after lung allografting in baboons'. Together they form a unique fingerprint.

Cite this