Functional and metabolic consequences of vitamin B-6 deficiency in the rat heart

A. M. Feldman, T. R. Guilarte, K. L. Baughman, Gary Gerstenblith

Research output: Contribution to journalArticle

Abstract

The cardiac functional and metabolic consequences of pyridoxine deficiency were studied in rats maintained on a pyridoxine-deficient diet for 10 weeks. Because food intake was diminished in the pyridoxine-deficient rats, a second group of animals was fed a diet restricted to the intake of the pyridoxine-deficient animals. The inotropic response (developed pressure) to an isoproterenol or Ca2+ concentration response curve was measured simultaneously with high energy phosphate levels using a modified Langendorf apparatus and 31P nuclear magnetic resonance spectroscopy. The inotropic response to Ca2+ and isoproterenol was significantly decreased relative to controls in both the food-deprived and the pyridoxine-deficient groups. Developed pressure after adrenergic stimulation was significantly less in the pyridoxine-deficient than in the food-deprived animals. Phosphocreatine and ATP levels were maintained and did not differ among the control, pyridoxine-deficient, and food-deprived groups during isoproterenol and Ca2+ stress, implying that the diminished inotropy was not due to an abnormality in generation of high energy phosphate levels.

Original languageEnglish (US)
Pages (from-to)31-39
Number of pages9
JournalExperimental Biology and Medicine
Volume184
Issue number1
StatePublished - 1987

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Vitamin B 6 Deficiency
Pyridoxine
Vitamin B 6
Rats
Isoproterenol
Animals
Food
Nutrition
Phosphates
Diet
Pressure
Phosphocreatine
Adrenergic Agents
Magnetic Resonance Spectroscopy
Nuclear magnetic resonance spectroscopy
Eating
Adenosine Triphosphate

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Functional and metabolic consequences of vitamin B-6 deficiency in the rat heart. / Feldman, A. M.; Guilarte, T. R.; Baughman, K. L.; Gerstenblith, Gary.

In: Experimental Biology and Medicine, Vol. 184, No. 1, 1987, p. 31-39.

Research output: Contribution to journalArticle

Feldman, A. M. ; Guilarte, T. R. ; Baughman, K. L. ; Gerstenblith, Gary. / Functional and metabolic consequences of vitamin B-6 deficiency in the rat heart. In: Experimental Biology and Medicine. 1987 ; Vol. 184, No. 1. pp. 31-39.
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