Function of the c-Myc oncogenic transcription factor

Chi V. Dang, Linda M.S. Resar, Eileen Emison, Sunkyu Kim, Qing Li, Julia E. Prescott, Diane Wonsey, Karen Zeller

Research output: Contribution to journalArticlepeer-review

Abstract

The c-myc gene and the expression of the c-Myc protein are frequently altered in human cancers. The c-myc gene encodes the transcription factor c- Myc, which heterodimerizes with a partner protein, termed Max, to regulate gene expression. Max also heterodimerizes with the Mad family of proteins to repress transcription, antagonize c-Myc, and promote cellular differentiation. The constitutive activation of c-myc expression is key to the genesis of many cancers, and hence the understanding of c-Myc function depends on our understanding of its target genes. In this review, we attempt to place the putative target genes of c-Myc in the context of c-Myc-mediated phenotypes. From this perspective, c-Myc emerges as an oncogenic transcription factor that integrates the cell cycle machinery with cell adhesion, cellular metabolism, and the apoptotic pathways.

Original languageEnglish (US)
Pages (from-to)63-77
Number of pages15
JournalExperimental cell research
Volume253
Issue number1
DOIs
StatePublished - Nov 25 1999

Keywords

  • Apoptosis
  • C-Myc
  • Cell adhesion
  • Cell cycle
  • Immortalization
  • Metabolism
  • Oncogene
  • Transcription factor

ASJC Scopus subject areas

  • Cell Biology

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