TY - JOUR
T1 - Function of nuclear co-repressor protein on thyroid hormone response elements is regulated by the receptor A/B domain
AU - Hollenberg, Anthony N.
AU - Monden, Tsuyoshi
AU - Madura, John P.
AU - Lee, Karen
AU - Wondisford, Fredric E.
PY - 1996
Y1 - 1996
N2 - Recently, a family of nuclear co-repressor proteins (TRACs) have been identified that interact with thyroid hormone (TR) and retinoic acid receptors to mediate ligand-independent repression of gene transcription. In this report, we have cloned and characterized a human TRAC, which when expressed as a truncated protein lacking its repressing domains, can abolish endogenous cellular TRAC activity. Use of this inhibitor has uncovered a differential function of TRACs on negative versus positive thyroid hormone response elements and has demonstrated the importance of the TR A/B domain in modulating TRAC function. Thus, isoform-specific functions of the TR may be mediated by their functional interaction with co-repressor proteins.
AB - Recently, a family of nuclear co-repressor proteins (TRACs) have been identified that interact with thyroid hormone (TR) and retinoic acid receptors to mediate ligand-independent repression of gene transcription. In this report, we have cloned and characterized a human TRAC, which when expressed as a truncated protein lacking its repressing domains, can abolish endogenous cellular TRAC activity. Use of this inhibitor has uncovered a differential function of TRACs on negative versus positive thyroid hormone response elements and has demonstrated the importance of the TR A/B domain in modulating TRAC function. Thus, isoform-specific functions of the TR may be mediated by their functional interaction with co-repressor proteins.
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U2 - 10.1074/jbc.271.45.28516
DO - 10.1074/jbc.271.45.28516
M3 - Article
C2 - 8910480
AN - SCOPUS:0029855771
VL - 271
SP - 28516
EP - 28520
JO - Journal of Biological Chemistry
JF - Journal of Biological Chemistry
SN - 0021-9258
IS - 45
ER -