Function of nuclear co-repressor protein on thyroid hormone response elements is regulated by the receptor A/B domain

Anthony N. Hollenberg, Tsuyoshi Monden, John P. Madura, Karen Lee, Fredric E. Wondisford

Research output: Contribution to journalArticlepeer-review

Abstract

Recently, a family of nuclear co-repressor proteins (TRACs) have been identified that interact with thyroid hormone (TR) and retinoic acid receptors to mediate ligand-independent repression of gene transcription. In this report, we have cloned and characterized a human TRAC, which when expressed as a truncated protein lacking its repressing domains, can abolish endogenous cellular TRAC activity. Use of this inhibitor has uncovered a differential function of TRACs on negative versus positive thyroid hormone response elements and has demonstrated the importance of the TR A/B domain in modulating TRAC function. Thus, isoform-specific functions of the TR may be mediated by their functional interaction with co-repressor proteins.

Original languageEnglish (US)
Pages (from-to)28516-28520
Number of pages5
JournalJournal of Biological Chemistry
Volume271
Issue number45
DOIs
StatePublished - 1996

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology

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