Function and regulation of the Arp2/3 complex during cell migration in diverse environments

Kristen F. Swaney, Rong Li

Research output: Contribution to journalArticle

Abstract

As the first de novo actin nucleator discovered, the Arp2/3 complex has been a central player in models of protrusive force production via the dynamic actin network. Here, we review recent studies on the functional role of the Arp2/3 complex in the migration of diverse cell types in different migratory environments. These findings have revealed an unexpected level of plasticity, both in how cells rely on the Arp2/3 complex for migration and other physiological functions and in the intricate modulation of the Arp2/3 complex by other actin regulators and upstream signaling cascades.

Original languageEnglish (US)
Pages (from-to)63-72
Number of pages10
JournalCurrent Opinion in Cell Biology
Volume42
DOIs
Publication statusPublished - Oct 1 2016

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ASJC Scopus subject areas

  • Cell Biology

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