Fulminant hepatic failure from primary hepatic lymphoma: Successful treatment with orthotopic liver transplantation and chemotherapy

Andrew M. Cameron, Jadwiga Truty, Jeff Truell, Charles Lassman, Michael A. Zimmerman, Burnett S. Kelly, Douglas G. Farmer, Jonathan R. Hiatt, Rafik Ghobrial, Ronald W. Busuttil

Research output: Contribution to journalArticlepeer-review

Abstract

Systemic lymphomas may involve the liver but rarely cause fulminant hepatic failure (FHF). Acute liver failure from primary hepatic lymphoma (PHL) is even less common with most patients succumbing to the sequelae of FHF before the correct diagnosis is made. We report a patient who underwent successful orthotopic liver transplant (OLT) and chemotherapy for FHF secondary to PHL. This previously-well male developed profound coagulopathy and encephalopathy 6 weeks after the onset of jaundice and fatigue. Workup failed to reveal the underlying cause of his liver failure and the patient soon required urgent OLT. Pathologic evaluation of his explanted liver revealed a malignant T-cell rich, large B-cell non-Hodgkin's lymphoma with widespread hepatocellular necrosis. The patient made an excellent clinical recovery and is undergoing CHOP-Rituxan chemotherapy. This scenario demonstrates that lymphoma should be considered in the differential diagnosis of FHF without clear etiology because of the potential for intervention with transplant and chemotherapy.

Original languageEnglish (US)
Pages (from-to)993-996
Number of pages4
JournalTransplantation
Volume80
Issue number7
DOIs
StatePublished - Oct 15 2005
Externally publishedYes

Keywords

  • Fulminant hepatic failure
  • Hodgkin's disease
  • Non-Hodgkin's lymphoma

ASJC Scopus subject areas

  • Transplantation

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