Fulminant encephalopathy with basal ganglia hyperintensities in HIV-infected drug users

S. D. Newsome, E. Johnson, C. Pardo, J. C. McArthur, A. Nath

Research output: Contribution to journalArticle

Abstract

Objective: To define a clinical syndrome associated with active drug abuse in HIV-infected individuals. Methods: We performed a retrospective review to identify individuals treated at the Johns Hopkins Hospital from 1993 to 2008 who were HIV-infected and were actively abusing drugs and had bilateral basal ganglia lesions on MRI. They were identified using a key word search in the radiology database, autopsy database, and the Moore HIV clinic database. Clinical, laboratory, and radiographic findings were correlated to define the syndrome. Results: Ten individuals were identified who presented with a change in mental status or seizures, used cocaine or cocaine with heroin, had uncontrolled HIV infection (>190,000 copies/mL of plasma), elevated CSF protein (63-313 mg/dL), and diffuse hyperintense bilateral basal ganglia lesions on imaging. The majority of patients (8/10) had renal failure and despite supportive therapy most (7/9) ultimately died (median survival 21 days). Postmortem examination in one individual showed the presence of overwhelming microglial activation in the basal ganglia. The 2 surviving individuals were started on combined antiretroviral therapy (CART) during hospitalization. Conclusion: We describe a unique clinical syndrome of a fulminant encephalopathy associated with primarily basal ganglia involvement in HIV-infected drug abusers. This syndrome is a rare but serious condition that is associated with a high mortality rate. Early CART institution may be useful and neuroprotective in this disorder, although this requires further investigation.

Original languageEnglish (US)
Pages (from-to)787-794
Number of pages8
JournalNeurology
Volume76
Issue number9
DOIs
StatePublished - Mar 1 2011

ASJC Scopus subject areas

  • Clinical Neurology

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