Full-genome scan for linkage in 50 families segregating the bipolar affective disease phenotype

Carl Friddle, Rebecca Koskela, Koustubh Ranade, Joan Hebert, Michele Cargill, Chris D. Clark, Melvin Mcinnis, Sylvia G. Simpson, Francis Joseph McMahon, O. Colin Stine, Deborah Meyers, Jianfeng Xu, Dean MacKinnon, Theresa Swift-Scanlan, Kay Jamison, Susan Folstein, Mark Daly, Leonid Kruglyak, Thomas Marr, J. Raymond DePauloDavid Botstein

Research output: Contribution to journalArticlepeer-review

65 Scopus citations


A genome scan of ~12-cM initial resolution was done on 50 of a set of 51 carefully ascertained unilineal multiplex families segregating the bipolar affective disorder phenotype. In addition to standard multipoint linkage analysis methods, a simultaneous-search algorithm was applied in an attempt to surmount the problem of genetic heterogeneity. The results revealed no linkage across the genome. The results exclude monogenic models and make it unlikely that two genes account for the disease in this sample. These results support the conclusion that at least several hundred kindreds will be required in order to establish linkage of susceptibility loci to bipolar disorder in heterogeneous populations.

Original languageEnglish (US)
Pages (from-to)205-215
Number of pages11
JournalAmerican journal of human genetics
Issue number1
StatePublished - 2000

ASJC Scopus subject areas

  • Genetics
  • Genetics(clinical)


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