@article{7c9602e7f61f4b0a8cb0804224d8a9e9,
title = "Full-genome scan for linkage in 50 families segregating the bipolar affective disease phenotype",
abstract = "A genome scan of ~12-cM initial resolution was done on 50 of a set of 51 carefully ascertained unilineal multiplex families segregating the bipolar affective disorder phenotype. In addition to standard multipoint linkage analysis methods, a simultaneous-search algorithm was applied in an attempt to surmount the problem of genetic heterogeneity. The results revealed no linkage across the genome. The results exclude monogenic models and make it unlikely that two genes account for the disease in this sample. These results support the conclusion that at least several hundred kindreds will be required in order to establish linkage of susceptibility loci to bipolar disorder in heterogeneous populations.",
author = "Carl Friddle and Rebecca Koskela and Koustubh Ranade and Joan Hebert and Michele Cargill and Clark, {Chris D.} and Melvin Mcinnis and Simpson, {Sylvia G.} and McMahon, {Francis Joseph} and Stine, {O. Colin} and Deborah Meyers and Jianfeng Xu and Dean MacKinnon and Theresa Swift-Scanlan and Kay Jamison and Susan Folstein and Mark Daly and Leonid Kruglyak and Thomas Marr and DePaulo, {J. Raymond} and David Botstein",
note = "Funding Information: This work was supported by grants from the Charles A. Dana Foundation Consortium on the Genetic Basis of Manic Depressive Illness, the National Institutes of Mental Health, the National Alliance for Research on Schizophrenia and Depression, and the Theodore and Vada Stanley Foundation and by contributors to the Affective Disorders Fund and the George Browne Laboratory Fund at Johns Hopkins University. We thank Paul McHugh and James Watson for their contributions to the planning of this study and for helpful criticism. We thank the residents and faculty of the Johns Hopkins University Department of Psychiatry, who referred families for this study. Finally, we thank the many families without whose collaboration this study would not have been possible. ",
year = "2000",
doi = "10.1086/302697",
language = "English (US)",
volume = "66",
pages = "205--215",
journal = "American journal of human genetics",
issn = "0002-9297",
publisher = "Cell Press",
number = "1",
}