Fuchs endothelial corneal dystrophy: Current perspectives

Gustavo Vedana, Guadalupe Villarreal, Albert S. Jun

Research output: Contribution to journalReview articlepeer-review

Abstract

Fuchs endothelial corneal dystrophy (FECD) is the most common corneal dystrophy and frequently results in vision loss. Hallmarks of the disease include loss of corneal endothelial cells and formation of excrescences of Descemet’s membrane. Later stages involve all layers of the cornea. Impairment of endothelial barrier and pump function and cell death from oxidative and unfolded protein stress contribute to disease progression. The genetic basis of FECD includes numerous genes and chromosomal loci, although alterations in the transcription factor 4 gene are associated with the majority of cases. Definitive treatment of FECD is corneal transplantation. In this paper, we highlight advances that have been made in understanding FECD’s clinical features, pathophysiology, and genetics. We also discuss recent advances in endothelial keratoplasty and potential future treatments.

Original languageEnglish (US)
Pages (from-to)321-330
Number of pages10
JournalClinical Ophthalmology
Volume10
DOIs
StatePublished - Feb 18 2016

Keywords

  • Corneal endothelial cell
  • Corneal transplantation
  • Descemet’s membrane endothelial keratoplasty
  • Descemet’s stripping automated endothelial keratoplasty
  • Endothelial keratoplasty
  • Fuchs endothelial corneal dystrophy

ASJC Scopus subject areas

  • Ophthalmology

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