Fuchs Endothelial Corneal Dystrophy: Clinical, Genetic, Pathophysiologic, and Therapeutic Aspects

Mario Matthaei, Agathe Hribek, Thomas Clahsen, Bjorn Bachmann, Claus Cursiefen, Albert S. Jun

Research output: Contribution to journalReview articlepeer-review


Fuchs endothelial corneal dystrophy (FECD) is a bilateral corneal endothelial disorder and the most common cause of corneal transplantation worldwide. Professor Ernst Fuchs described the first 13 cases of FECD more than 100 years ago. Since then, we have seen far-reaching progress in its diagnosis and treatment. In the field of diagnostics, new technologies enable the development of more accurate classification systems and the more detailed breakdown of the genetic basis of FECD. Laboratory studies help in deciphering the molecular pathomechanisms. The development of minimally invasive surgical techniques leads to a continuous improvement of the postoperative result. This review highlights and discusses clinical, genetic, pathophysiologic, and therapeutic aspects of this common and important corneal disorder.

Original languageEnglish (US)
Pages (from-to)151-175
Number of pages25
JournalAnnual review of vision science
StatePublished - Sep 15 2019


  • FECD
  • Fuchs endothelial corneal dystrophy
  • corneal dystrophy
  • corneal endothelium
  • keratoplasty

ASJC Scopus subject areas

  • Ophthalmology
  • Clinical Neurology


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