Fuchs corneal dystrophy

Research output: Contribution to journalReview article

Abstract

Fuchs corneal dystrophy (FCD) is a progressive, hereditary disease of the cornea first described a century ago by the Austrian ophthalmologist Ernst Fuchs. Patients often present in the fifth to sixth decade of life with blurry morning vision that increases in duration as the disease progresses. Primarily a condition of the posterior cornea, characteristic features include the formation of focal excrescences of Descemet membrane termed 'guttae, loss of endothelial cell density and end-stage disease manifested by corneal edema and the formation of epithelial bullae. Recent advances in our understanding of the genetic and pathophysiological mechanisms of the disease, as well as the application of new imaging modalities and less invasive surgical procedures, present new opportunities for improved outcomes among patients with FCD.

Original languageEnglish (US)
Pages (from-to)147-159
Number of pages13
JournalExpert Review of Ophthalmology
Volume5
Issue number2
DOIs
StatePublished - Apr 1 2010

Keywords

  • DSEK
  • Descemet membrane
  • Endothelium
  • Fuchs corneal dystrophy
  • Guttae

ASJC Scopus subject areas

  • Biomedical Engineering
  • Ophthalmology
  • Optometry

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