Fruit and vegetable consumption, intake of micronutrients, and benign prostatic hyperplasia in US men

Sabine Rohrmann, Edward Giovannucci, Walter C. Willett, Elizabeth A. Platz

Research output: Contribution to journalArticlepeer-review

Abstract

Background: Nutrients with antioxidant properties or that influence cell growth and differentiation might reduce the risk of benign prostatic hyperplasia (BPH). Objective: The objective was to evaluate the association of fruit, vegetable, and micronutrient intakes with BPH. Design: The participants were members of the Health Professionals Follow-Up Study and were aged 46-81 y in 1992. In 1992 and biennially thereafter, the men reported having surgery for an enlarged prostate, and in 1992 and on 3 subsequent questionnaires they completed the American Urological Association symptom index (AUASI). BPH cases were men who reported having surgery or who had an AUASI score of 15-35 (n = 6092). Control subjects were men who had not had surgery and never had an AUASI score >7 (n = 18 373). Men with a score of 8-14 were excluded (n = 7800). Intakes of fruit, vegetables, and antioxidants were assessed with a food-frequency questionnaire in 1986. We calculated odds ratios (ORs) of BPH and 95% CIs using logistic regression. Results: Vegetable consumption was inversely associated with BPH (fifth compared with first quintile - OR: 0.89; 95% CI: 0.80, 0.99; P for trend = 0.03), whereas fruit intake was not. Consumption of fruit and vegetables rich in β-carotene (P for trend = 0.004), lutein (P for trend = 0.0004), or vitamin C (P for trend = 0.05) was inversely related to BPH. With increasing vitamin C intake from foods, men were less likely to have BPH (P for trend = 0.0009). Neither α- nor γ-tocopherol intake from foods was associated with BPH (P for trend γ 0.05 and 0.84, respectively). Conclusion: Our findings are consistent with the hypothesis that a diet rich in vegetables may reduce the occurrence of BPH.

Original languageEnglish (US)
Pages (from-to)523-529
Number of pages7
JournalAmerican Journal of Clinical Nutrition
Volume85
Issue number2
DOIs
StatePublished - Feb 1 2007

Keywords

  • Benign prostatic hyperplasia
  • Fruit
  • Micronutrients
  • Vegetables

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Nutrition and Dietetics

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