Frozen section evaluation of preimplantation donor kidneys: Application of the Maryland aggregate pathology index

Thomas A. Huebner, John C. Papadimitriou, Cinthia B. Drachenberg, Annie Gonzalez, Benjamin Philosophe, Raghava B. Munivenkatappa

Research output: Contribution to journalArticle

Abstract

The benefits of renal transplantation for patients with end-stage renal disease on hemodialysis are well established, but currently there is a significant shortage of organs available for transplantation. In an effort to increase the size of the donor pool, donors that may have been excluded from donating previously are currently accepted. Frozen section evaluation of preimplantation donor kidney biopsies is particularly important for organs from these expanded criteria donors, both to determine organ suitability and as a tool to predict short- and long-term graft survival. Although significant progress has been made in the field, controversy still remains regarding the predictive value of the individual pathologic parameters to predict graft outcome. The Maryland Aggregate Pathology Index score is based on the identification of 5 histologic parameters and is used to stratify donor organs into low-, intermediate-, and high-risk groups, which correlate with overall graft survival. Irrespectively of the transplant donor population, preimplantation donor kidney frozen section evaluation is an invaluable tool for optimal use of the available organs.

Original languageEnglish (US)
Pages (from-to)174-179
Number of pages6
JournalPathology Case Reviews
Volume15
Issue number5
DOIs
StatePublished - Sep 2010
Externally publishedYes

Fingerprint

Frozen Sections
Tissue Donors
Pathology
Kidney
Graft Survival
Organ Transplantation
Kidney Transplantation
Chronic Kidney Failure
Renal Dialysis
Transplants
Biopsy
Population

Keywords

  • biopsy
  • diabetes
  • expanded criteria donor
  • hypertension
  • organ selection
  • transplant
  • United Network for Organ Sharing

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

Cite this

Frozen section evaluation of preimplantation donor kidneys : Application of the Maryland aggregate pathology index. / Huebner, Thomas A.; Papadimitriou, John C.; Drachenberg, Cinthia B.; Gonzalez, Annie; Philosophe, Benjamin; Munivenkatappa, Raghava B.

In: Pathology Case Reviews, Vol. 15, No. 5, 09.2010, p. 174-179.

Research output: Contribution to journalArticle

Huebner, Thomas A. ; Papadimitriou, John C. ; Drachenberg, Cinthia B. ; Gonzalez, Annie ; Philosophe, Benjamin ; Munivenkatappa, Raghava B. / Frozen section evaluation of preimplantation donor kidneys : Application of the Maryland aggregate pathology index. In: Pathology Case Reviews. 2010 ; Vol. 15, No. 5. pp. 174-179.
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