Frontotemporal lobar degeneration: A consensus on clinical diagnostic criteria

D. Neary, J. S. Snowden, L. Gustafson, U. Passant, D. Stuss, S. Black, M. Freedman, A. Kertesz, P. H. Robert, Marilyn Albert, K. Boone, B. L. Miller, J. Cummings, D. F. Benson

Research output: Contribution to journalArticle

Abstract

Objective: To improve clinical recognition and provide research diagnostic criteria for three clinical syndromes associated with frontotemporal lobar degeneration. Methods: Consensus criteria for the three prototypic syndromes-frontotemporal dementia, progressive nonfluent aphasia, and semantic dementia-were developed by members of an international workshop on frontotemporal lobar degeneration. These criteria build on earlier published clinical diagnostic guidelines for frontotemporal dementia produced by some of the workshop members. Results: The consensus criteria specify core and supportive features for each of the three prototypic clinical syndromes and provide broad inclusion and exclusion criteria for the generic entity of frontotemporal lobar degeneration. The criteria are presented in lists, and operational definitions for features are provided in the text. Conclusions: The criteria ought to provide the foundation for research work into the neuropsychology, neuropathology, genetics, molecular biology, and epidemiology of these important clinical disorders that account for a substantial proportion of cases of primary degenerative dementia occurring before the age of 65 years.

Original languageEnglish (US)
Pages (from-to)1546-1554
Number of pages9
JournalNeurology
Volume51
Issue number6
StatePublished - Dec 1998
Externally publishedYes

Fingerprint

Frontotemporal Lobar Degeneration
Frontotemporal Dementia
Consensus
Primary Progressive Nonfluent Aphasia
Education
Neuropsychology
Molecular Epidemiology
Research
Dementia
Molecular Biology
Guidelines

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Neary, D., Snowden, J. S., Gustafson, L., Passant, U., Stuss, D., Black, S., ... Benson, D. F. (1998). Frontotemporal lobar degeneration: A consensus on clinical diagnostic criteria. Neurology, 51(6), 1546-1554.

Frontotemporal lobar degeneration : A consensus on clinical diagnostic criteria. / Neary, D.; Snowden, J. S.; Gustafson, L.; Passant, U.; Stuss, D.; Black, S.; Freedman, M.; Kertesz, A.; Robert, P. H.; Albert, Marilyn; Boone, K.; Miller, B. L.; Cummings, J.; Benson, D. F.

In: Neurology, Vol. 51, No. 6, 12.1998, p. 1546-1554.

Research output: Contribution to journalArticle

Neary, D, Snowden, JS, Gustafson, L, Passant, U, Stuss, D, Black, S, Freedman, M, Kertesz, A, Robert, PH, Albert, M, Boone, K, Miller, BL, Cummings, J & Benson, DF 1998, 'Frontotemporal lobar degeneration: A consensus on clinical diagnostic criteria', Neurology, vol. 51, no. 6, pp. 1546-1554.
Neary D, Snowden JS, Gustafson L, Passant U, Stuss D, Black S et al. Frontotemporal lobar degeneration: A consensus on clinical diagnostic criteria. Neurology. 1998 Dec;51(6):1546-1554.
Neary, D. ; Snowden, J. S. ; Gustafson, L. ; Passant, U. ; Stuss, D. ; Black, S. ; Freedman, M. ; Kertesz, A. ; Robert, P. H. ; Albert, Marilyn ; Boone, K. ; Miller, B. L. ; Cummings, J. ; Benson, D. F. / Frontotemporal lobar degeneration : A consensus on clinical diagnostic criteria. In: Neurology. 1998 ; Vol. 51, No. 6. pp. 1546-1554.
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