TY - JOUR
T1 - Frontotemporal dementia
AU - Bang, Jee
AU - Spina, Salvatore
AU - Miller, Bruce L.
N1 - Funding Information:
University of California, San Francisco; Alzheimer Disease Research Center; Program Project Grant; the Tau Consortium; and the Consortium for Frontotemporal Dementia Research provided funding for this report. We thank Caroline Latham and John Fesenko for their help with the rendition and editing of the illustrations. We thank William W Seeley for providing the neuropathological illustrations.
Publisher Copyright:
© 2015 Elsevier Ltd.
PY - 2015/10/24
Y1 - 2015/10/24
N2 - Frontotemporal dementia is an umbrella clinical term that encompasses a group of neurodegenerative diseases characterised by progressive deficits in behaviour, executive function, or language. Frontotemporal dementia is a common type of dementia, particularly in patients younger than 65 years. The disease can mimic many psychiatric disorders because of the prominent behavioural features. Various underlying neuropathological entities lead to the frontotemporal dementia clinical phenotype, all of which are characterised by the selective degeneration of the frontal and temporal cortices. Genetics is an important risk factor for frontotemporal dementia. Advances in clinical, imaging, and molecular characterisation have increased the accuracy of frontotemporal dementia diagnosis, thus allowing for the accurate differentiation of these syndromes from psychiatric disorders. As the understanding of the molecular basis for frontotemporal dementia improves, rational therapies are beginning to emerge.
AB - Frontotemporal dementia is an umbrella clinical term that encompasses a group of neurodegenerative diseases characterised by progressive deficits in behaviour, executive function, or language. Frontotemporal dementia is a common type of dementia, particularly in patients younger than 65 years. The disease can mimic many psychiatric disorders because of the prominent behavioural features. Various underlying neuropathological entities lead to the frontotemporal dementia clinical phenotype, all of which are characterised by the selective degeneration of the frontal and temporal cortices. Genetics is an important risk factor for frontotemporal dementia. Advances in clinical, imaging, and molecular characterisation have increased the accuracy of frontotemporal dementia diagnosis, thus allowing for the accurate differentiation of these syndromes from psychiatric disorders. As the understanding of the molecular basis for frontotemporal dementia improves, rational therapies are beginning to emerge.
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U2 - 10.1016/S0140-6736(15)00461-4
DO - 10.1016/S0140-6736(15)00461-4
M3 - Review article
C2 - 26595641
AN - SCOPUS:84945340060
SN - 0140-6736
VL - 386
SP - 1672
EP - 1682
JO - The Lancet
JF - The Lancet
IS - 10004
ER -