Frontotemporal dementia

Jee Bang, Salvatore Spina, Bruce L. Miller

Research output: Contribution to journalReview article

Abstract

Frontotemporal dementia is an umbrella clinical term that encompasses a group of neurodegenerative diseases characterised by progressive deficits in behaviour, executive function, or language. Frontotemporal dementia is a common type of dementia, particularly in patients younger than 65 years. The disease can mimic many psychiatric disorders because of the prominent behavioural features. Various underlying neuropathological entities lead to the frontotemporal dementia clinical phenotype, all of which are characterised by the selective degeneration of the frontal and temporal cortices. Genetics is an important risk factor for frontotemporal dementia. Advances in clinical, imaging, and molecular characterisation have increased the accuracy of frontotemporal dementia diagnosis, thus allowing for the accurate differentiation of these syndromes from psychiatric disorders. As the understanding of the molecular basis for frontotemporal dementia improves, rational therapies are beginning to emerge.

Original languageEnglish (US)
Pages (from-to)1672-1682
Number of pages11
JournalThe Lancet
Volume386
Issue number10004
DOIs
StatePublished - Oct 24 2015

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ASJC Scopus subject areas

  • Medicine(all)

Cite this

Bang, J., Spina, S., & Miller, B. L. (2015). Frontotemporal dementia. The Lancet, 386(10004), 1672-1682. https://doi.org/10.1016/S0140-6736(15)00461-4