Frontiers in ATP synthase research: Understanding the relationship between subunit movements and ATP synthesis

Peter L. Pedersen

Research output: Contribution to journalReview articlepeer-review

Abstract

How biological systems make ATP has intrigued many scientists for well over half the 20th century, and because of the importance and complexity of the problem it seems likely to continue to be a source of fascination to both senior and younger investigators well into the 21st century. Scientific battles fought to unravel the vast secrets by which ATP synthases work have been fierce, and great victories have been short-lived, tempered with the realization that more structures are needed, additional subunits remain to be conquered, and that during ATP synthesis, not one, but several subunits may undergo either significant conformational changes, repositioning, or perhaps even physical 'rotation' similar to bacterial flagella. In this introductory article, the author briefly summarizes our current knowledge about the complex substructure of ATP synthases, what we have learned from X-ray crystallography of the F1 unit, and current evidence for subunit movements.

Original languageEnglish (US)
Pages (from-to)389-395
Number of pages7
JournalJournal of Bioenergetics and Biomembranes
Volume28
Issue number5
DOIs
StatePublished - 1996

Keywords

  • ATP synthase
  • ATP synthesis
  • F-ATPase
  • mitochondrial function
  • molecular motors
  • oxidative phosphorylation
  • subunit movements
  • subunit rotation

ASJC Scopus subject areas

  • Physiology
  • Cell Biology

Fingerprint

Dive into the research topics of 'Frontiers in ATP synthase research: Understanding the relationship between subunit movements and ATP synthesis'. Together they form a unique fingerprint.

Cite this