Frontal and motor cortex contributions to response inhibition: Evidence from electrocorticography

Yvonne M. Fonken, Jochem W. Rieger, Elinor Tzvi, Nathan E. Crone, Edward Chang, Josef Parvizi, Robert T. Knight, Ulrike M. Krämer

Research output: Contribution to journalArticlepeer-review

Abstract

Changes in the environment require rapid modification or inhibition of ongoing behavior. We used the stop-signal paradigm and intracranial recordings to investigate response preparation, inhibition, and monitoring of task-relevant information. Electrocorticographic data were recorded in eight patients with electrodes covering frontal, temporal, and parietal cortex, and time-frequency analysis was used to examine power differences in the beta (13–30 Hz) and high-gamma bands (60–180 Hz). Over motor cortex, beta power decreased, and high-gamma power increased during motor preparation for both go trials (Go) and unsuccessful stops (US). For successful stops (SS), beta increased, and high-gamma was reduced, indexing the cancellation of the prepared response. In the middle frontal gyrus (MFG), stop signals elicited a transient high-gamma increase. The MFG response occurred before the estimated stop-signal reaction time but did not distinguish between SS and US trials, likely signaling attention to the salient stop stimulus. A postresponse high-gamma increase in MFG was stronger for US compared with SS and absent in Go, supporting a role in behavior monitoring. These results provide evidence for differential contributions of frontal subregions to response inhibition, including motor preparation and inhibitory control in motor cortex and cognitive control and action evaluation in lateral prefrontal cortex.

Original languageEnglish (US)
Pages (from-to)2224-2236
Number of pages13
JournalJournal of neurophysiology
Volume115
Issue number4
DOIs
StatePublished - Apr 1 2016

Keywords

  • Beta oscillations
  • Electrocorticography
  • High gamma
  • Motor control
  • Stop-signal task

ASJC Scopus subject areas

  • Neuroscience(all)
  • Physiology

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