From the genome to the phenome and back: Linking genes with human brain function and structure using genetically informed neuroimaging

H. R. Siebner, J. H. Callicott, T. Sommer, V. S. Mattay

Research output: Contribution to journalEditorialpeer-review

Abstract

In recent years, an array of brain mapping techniques has been successfully employed to link individual differences in circuit function or structure in the living human brain with individual variations in the human genome. Several proof-of-principle studies provided converging evidence that brain imaging can establish important links between genes and behaviour. The overarching goal is to use genetically informed brain imaging to pinpoint neurobiological mechanisms that contribute to behavioural intermediate phenotypes or disease states. This special issue on "Linking Genes to Brain Function in Health and Disease" provides an overview over how the "imaging genetics" approach is currently applied in the various fields of systems neuroscience to reveal the genetic underpinnings of complex behaviours and brain diseases. While the rapidly emerging field of imaging genetics holds great promise, the integration of genetic and neuroimaging data also poses major methodological and conceptual challenges. Therefore, this special issue also focuses on how these challenges can be met to fully exploit the synergism of genetically informed brain imaging.

Original languageEnglish (US)
Pages (from-to)1-6
Number of pages6
JournalNeuroscience
Volume164
Issue number1
DOIs
StatePublished - Nov 24 2009
Externally publishedYes

Keywords

  • Brain mapping
  • Genome
  • Imaging genetics
  • Neuroimaging
  • Phenomics

ASJC Scopus subject areas

  • Neuroscience(all)

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