From sulfenylation to sulfhydration: What a thiolate needs to tolerate

Toren Finkel

doi:10.1126/scisignal.2002943

From sulfenylation to sulfhydration: What a thiolate needs to tolerate

Toren Finkel

Research output: Contribution to journal › Article › peer-review

98 Scopus citations

Abstract

There is a growing appreciation that oxidants such as hydrogen peroxide (H ₂O ₂) and gasses such as nitric oxide (NO) and hydrogen sulfide (H ₂S) can act as modulators of various signaling pathways. Much of this signaling occurs through the modifications of specific, critical cysteine residues in target proteins. How such small diffusible molecules (H ₂O ₂, NO, H ₂S) can achieve the required specificity is incompletely understood. Now, new findings provide considerable insight into these and related questions.

Original language	English (US)
Article number	pe10
Journal	Science Signaling
Volume	5
Issue number	215
DOIs	https://doi.org/10.1126/scisignal.2002943
State	Published - Mar 13 2012
Externally published	Yes

ASJC Scopus subject areas

Biochemistry
Cell Biology
Molecular Biology

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10.1126/scisignal.2002943

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From sulfenylation to sulfhydration: What a thiolate needs to tolerate

Abstract

ASJC Scopus subject areas

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