From structure to disease: The evolving tale of aquaporin biology

Landon S. King, David Kozono, Peter Agre

Research output: Contribution to journalReview articlepeer-review

700 Scopus citations


Our understanding of the movement of water through cell membranes has been greatly advanced by the discovery of a family of water-specific, membrane-channel proteins - the aquaporins. These proteins are present in organisms at all levels of life, and their unique permeability characteristics and distribution in numerous tissues indicate diverse roles in the regulation of water homeostasis. The recognition of aquaporins has stimulated a reconsideration of membrane water permeability by investigators across a wide range of disciplines.

Original languageEnglish (US)
Pages (from-to)687-698
Number of pages12
JournalNature Reviews Molecular Cell Biology
Issue number9
StatePublished - Sep 2004
Externally publishedYes

ASJC Scopus subject areas

  • Molecular Biology
  • Cell Biology


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