Abstract
Mechanical loads are vital regulators of skeletal mass and architecture as evidenced by the increase in bone formation following the addition of exogenous loads and loss of bone mass following their removal. While our understanding of the molecular mechanisms by which bone cells perceive changes in their mechanical environment has increased rapidly in recent years, much remains to be learned. Here, we outline the effects of interstitial fluid flow, a potent biophysical signal induced by the deformation of skeletal tissue in response to applied loads, on bone cell behavior. We focus on the molecular mechanisms by which bone cells are hypothesized to perceive interstitial fluid flow, the cell signaling cascades activated by fluid flow, and the use of this signal in tissue engineering protocols.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 143-149 |
| Number of pages | 7 |
| Journal | Journal of Orthopaedic Research |
| Volume | 27 |
| Issue number | 2 |
| DOIs | |
| State | Published - Feb 2009 |
| Externally published | Yes |
Fingerprint
Keywords
- Interstitial fluid flow
- Mechanical load
- Osteoblast
- Osteocyte
- Streaming potentials
ASJC Scopus subject areas
- Orthopedics and Sports Medicine
- Medicine(all)
Cite this
From streaming potentials to shear stress : 25 Years of bone cell mechanotransduction. / Riddle, Ryan; Donahue, Henry J.
In: Journal of Orthopaedic Research, Vol. 27, No. 2, 02.2009, p. 143-149.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - From streaming potentials to shear stress
T2 - 25 Years of bone cell mechanotransduction
AU - Riddle, Ryan
AU - Donahue, Henry J.
PY - 2009/2
Y1 - 2009/2
N2 - Mechanical loads are vital regulators of skeletal mass and architecture as evidenced by the increase in bone formation following the addition of exogenous loads and loss of bone mass following their removal. While our understanding of the molecular mechanisms by which bone cells perceive changes in their mechanical environment has increased rapidly in recent years, much remains to be learned. Here, we outline the effects of interstitial fluid flow, a potent biophysical signal induced by the deformation of skeletal tissue in response to applied loads, on bone cell behavior. We focus on the molecular mechanisms by which bone cells are hypothesized to perceive interstitial fluid flow, the cell signaling cascades activated by fluid flow, and the use of this signal in tissue engineering protocols.
AB - Mechanical loads are vital regulators of skeletal mass and architecture as evidenced by the increase in bone formation following the addition of exogenous loads and loss of bone mass following their removal. While our understanding of the molecular mechanisms by which bone cells perceive changes in their mechanical environment has increased rapidly in recent years, much remains to be learned. Here, we outline the effects of interstitial fluid flow, a potent biophysical signal induced by the deformation of skeletal tissue in response to applied loads, on bone cell behavior. We focus on the molecular mechanisms by which bone cells are hypothesized to perceive interstitial fluid flow, the cell signaling cascades activated by fluid flow, and the use of this signal in tissue engineering protocols.
KW - Interstitial fluid flow
KW - Mechanical load
KW - Osteoblast
KW - Osteocyte
KW - Streaming potentials
UR - http://www.scopus.com/inward/record.url?scp=59449089119&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=59449089119&partnerID=8YFLogxK
U2 - 10.1002/jor.20723
DO - 10.1002/jor.20723
M3 - Article
C2 - 18683882
AN - SCOPUS:59449089119
VL - 27
SP - 143
EP - 149
JO - Journal of Orthopaedic Research
JF - Journal of Orthopaedic Research
SN - 0736-0266
IS - 2
ER -