From spikes to EEG: Integrated multichannel and selective acquisition of neuropotentials

Mohsen Mollazadeh, Kartikeya Murari, Gert Cauwenberghs, Nitish V Thakor

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Electrical signals recorded from the brain cover a wide range of amplitudes, frequencies, and spatial scales, from spikes and local field potentials (LFP) inside the brain to electrocorticograms (ECoG) and electroencepalograms (EEG) outside. Each of these signal modalities represent different aspects of neural dynamics that can be combined to infer brain state and function in a broader context. We present a 16-channel interface circuit fabricated in a 0.5μm CMOS process for the selective acquisition and digitization of any of the modalities. Each channel features a fixed gain bandpass amplifier with a tunable frequency response which allows isolation of the signal of interest without hardware modification and a programmable gain/resolution analog to digital converter (ADC). The bandpass amplifier analog front end has an input referred noise of 1.94 μVrms for a bandwidth of 8.2 kHz while drawing 12.2 μA of current from a 3.3 V supply. Experimental recordings with the system show spike signals in rat somatosensory cortex as well as alpha EEG activity in a human subject.

Original languageEnglish (US)
Title of host publicationProceedings of the 30th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS'08 - "Personalized Healthcare through Technology"
Pages2741-2744
Number of pages4
StatePublished - 2008
Event30th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS'08 - Vancouver, BC, Canada
Duration: Aug 20 2008Aug 25 2008

Other

Other30th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS'08
CountryCanada
CityVancouver, BC
Period8/20/088/25/08

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ASJC Scopus subject areas

  • Computer Vision and Pattern Recognition
  • Signal Processing
  • Biomedical Engineering
  • Health Informatics

Cite this

Mollazadeh, M., Murari, K., Cauwenberghs, G., & Thakor, N. V. (2008). From spikes to EEG: Integrated multichannel and selective acquisition of neuropotentials. In Proceedings of the 30th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS'08 - "Personalized Healthcare through Technology" (pp. 2741-2744). [4649769]