TY - GEN
T1 - From spikes to EEG
T2 - 30th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS'08
AU - Mollazadeh, Mohsen
AU - Murari, Kartikeya
AU - Cauwenberghs, Gert
AU - Thakor, Nitish
N1 - Copyright:
Copyright 2020 Elsevier B.V., All rights reserved.
PY - 2008
Y1 - 2008
N2 - Electrical signals recorded from the brain cover a wide range of amplitudes, frequencies, and spatial scales, from spikes and local field potentials (LFP) inside the brain to electrocorticograms (ECoG) and electroencepalograms (EEG) outside. Each of these signal modalities represent different aspects of neural dynamics that can be combined to infer brain state and function in a broader context. We present a 16-channel interface circuit fabricated in a 0.5μm CMOS process for the selective acquisition and digitization of any of the modalities. Each channel features a fixed gain bandpass amplifier with a tunable frequency response which allows isolation of the signal of interest without hardware modification and a programmable gain/resolution analog to digital converter (ADC). The bandpass amplifier analog front end has an input referred noise of 1.94 μVrms for a bandwidth of 8.2 kHz while drawing 12.2 μA of current from a 3.3 V supply. Experimental recordings with the system show spike signals in rat somatosensory cortex as well as alpha EEG activity in a human subject.
AB - Electrical signals recorded from the brain cover a wide range of amplitudes, frequencies, and spatial scales, from spikes and local field potentials (LFP) inside the brain to electrocorticograms (ECoG) and electroencepalograms (EEG) outside. Each of these signal modalities represent different aspects of neural dynamics that can be combined to infer brain state and function in a broader context. We present a 16-channel interface circuit fabricated in a 0.5μm CMOS process for the selective acquisition and digitization of any of the modalities. Each channel features a fixed gain bandpass amplifier with a tunable frequency response which allows isolation of the signal of interest without hardware modification and a programmable gain/resolution analog to digital converter (ADC). The bandpass amplifier analog front end has an input referred noise of 1.94 μVrms for a bandwidth of 8.2 kHz while drawing 12.2 μA of current from a 3.3 V supply. Experimental recordings with the system show spike signals in rat somatosensory cortex as well as alpha EEG activity in a human subject.
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U2 - 10.1109/iembs.2008.4649769
DO - 10.1109/iembs.2008.4649769
M3 - Conference contribution
C2 - 19163272
AN - SCOPUS:61849107412
SN - 9781424418152
T3 - Proceedings of the 30th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS'08 - "Personalized Healthcare through Technology"
SP - 2741
EP - 2744
BT - Proceedings of the 30th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS'08
PB - IEEE Computer Society
Y2 - 20 August 2008 through 25 August 2008
ER -