From microbe to man: The role of microbial short chain fatty acid metabolites in host cell biology

Niranjana Natarajan, Jennifer L. Pluznick

Research output: Contribution to journalReview articlepeer-review

Abstract

Recent studies have highlighted a myriad of ways in which the activity and composition of the gut microbiota can affect the host organism. A primary way in which the gut microbiota affect host physiology is by the production of metabolites, such as short-chain fatty acids (SCFAs), which are subsequently absorbed into the bloodstream of the host. Although recent studies have begun to unravel the ways in which gut microbial SCFAs affect host physiology, less is understood regarding the underlying cell biological mechanisms. In this review, we will outline the known receptors and transporters for SCFAs, and review what is known about the cell biological effects of microbial SCFAs.

Original languageEnglish (US)
Pages (from-to)C979-C985
JournalAmerican Journal of Physiology - Cell Physiology
Volume307
Issue number11
DOIs
StatePublished - Dec 1 2014

Keywords

  • Gpr41
  • Gpr43
  • Microbiota
  • Olfr78
  • SCFAs

ASJC Scopus subject areas

  • Physiology
  • Cell Biology

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