From Krebs to clinic: glutamine metabolism to cancer therapy

Brian J. Altman; Zachary E. Stine; Chi V. Dang

doi:10.1038/nrc.2016.71

From Krebs to clinic: glutamine metabolism to cancer therapy

Brian J. Altman, Zachary E. Stine, Chi V. Dang

Research output: Contribution to journal › Article › peer-review

Abstract

The resurgence of research into cancer metabolism has recently broadened interests beyond glucose and the Warburg effect to other nutrients, including glutamine. Because oncogenic alterations of metabolism render cancer cells addicted to nutrients, pathways involved in glycolysis or glutaminolysis could be exploited for therapeutic purposes. In this Review, we provide an updated overview of glutamine metabolism and its involvement in tumorigenesis in vitro and in vivo, and explore the recent potential applications of basic science discoveries in the clinical setting.

Original language	English (US)
Journal	Nature Reviews Cancer
DOIs	https://doi.org/10.1038/nrc.2016.71
State	Accepted/In press - Jul 29 2016
Externally published	Yes

ASJC Scopus subject areas

Medicine(all)
Oncology
Cancer Research

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