@article{a5d122092b0c49b2b2f5752619faa387,
title = "From Krebs to clinic: Glutamine metabolism to cancer therapy",
abstract = "The resurgence of research into cancer metabolism has recently broadened interests beyond glucose and the Warburg effect to other nutrients, including glutamine. Because oncogenic alterations of metabolism render cancer cells addicted to nutrients, pathways involved in glycolysis or glutaminolysis could be exploited for therapeutic purposes. In this Review, we provide an updated overview of glutamine metabolism and its involvement in tumorigenesis in vitro and in vivo, and explore the recent potential applications of basic science discoveries in the clinical setting.",
author = "Altman, {Brian J.} and Stine, {Zachary E.} and Dang, {Chi V.}",
note = "Funding Information: The authors thank R. DeBerardinis (Children's Research Institute at University of Texas Southwestern, Dallas, USA) and J. Coloff (Department of Cell Biology, Harvard Medical School, Boston, Massachusetts, USA) for helpful commentary and discussion. They apologize to any authors whose work could not be included owing to space limitations. This work is artially supported by the National Cancer Institute (NCI) of the National Institutes of Health (NIH) (R01CA057341 (C.V.D)), The Leukemia and Lymphoma Society LLS 6106-14 (C.V.D.) and the Abramson Family Cancer Research Institute. B.J.A. and Z.E.S. were supported by the NCI (F32CA180370 and F32CA174148, respectively). Publisher Copyright: {\textcopyright} 2016 Macmillan Publishers Limited.",
year = "2016",
month = sep,
day = "23",
doi = "10.1038/nrc.2016.71",
language = "English (US)",
volume = "16",
pages = "619--634",
journal = "Nature Reviews Cancer",
issn = "1474-175X",
publisher = "Nature Publishing Group",
number = "10",
}