Abstract
The resurgence of research into cancer metabolism has recently broadened interests beyond glucose and the Warburg effect to other nutrients, including glutamine. Because oncogenic alterations of metabolism render cancer cells addicted to nutrients, pathways involved in glycolysis or glutaminolysis could be exploited for therapeutic purposes. In this Review, we provide an updated overview of glutamine metabolism and its involvement in tumorigenesis in vitro and in vivo, and explore the recent potential applications of basic science discoveries in the clinical setting.
| Original language | English (US) |
|---|---|
| Journal | Nature Reviews Cancer |
| DOIs | |
| State | Accepted/In press - Jul 29 2016 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Medicine(all)
- Oncology
- Cancer Research
Cite this
From Krebs to clinic : glutamine metabolism to cancer therapy. / Altman, Brian J.; Stine, Zachary E.; Dang, Chi V.
In: Nature Reviews Cancer, 29.07.2016.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - From Krebs to clinic
T2 - glutamine metabolism to cancer therapy
AU - Altman, Brian J.
AU - Stine, Zachary E.
AU - Dang, Chi V.
PY - 2016/7/29
Y1 - 2016/7/29
N2 - The resurgence of research into cancer metabolism has recently broadened interests beyond glucose and the Warburg effect to other nutrients, including glutamine. Because oncogenic alterations of metabolism render cancer cells addicted to nutrients, pathways involved in glycolysis or glutaminolysis could be exploited for therapeutic purposes. In this Review, we provide an updated overview of glutamine metabolism and its involvement in tumorigenesis in vitro and in vivo, and explore the recent potential applications of basic science discoveries in the clinical setting.
AB - The resurgence of research into cancer metabolism has recently broadened interests beyond glucose and the Warburg effect to other nutrients, including glutamine. Because oncogenic alterations of metabolism render cancer cells addicted to nutrients, pathways involved in glycolysis or glutaminolysis could be exploited for therapeutic purposes. In this Review, we provide an updated overview of glutamine metabolism and its involvement in tumorigenesis in vitro and in vivo, and explore the recent potential applications of basic science discoveries in the clinical setting.
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UR - http://www.scopus.com/inward/citedby.url?scp=84982993825&partnerID=8YFLogxK
U2 - 10.1038/nrc.2016.71
DO - 10.1038/nrc.2016.71
M3 - Article
C2 - 27492215
AN - SCOPUS:84982993825
JO - Nature Reviews Cancer
JF - Nature Reviews Cancer
SN - 1474-175X
ER -