From Krebs to clinic: glutamine metabolism to cancer therapy

Brian J. Altman, Zachary E. Stine, Chi V. Dang

Research output: Contribution to journalArticle

Abstract

The resurgence of research into cancer metabolism has recently broadened interests beyond glucose and the Warburg effect to other nutrients, including glutamine. Because oncogenic alterations of metabolism render cancer cells addicted to nutrients, pathways involved in glycolysis or glutaminolysis could be exploited for therapeutic purposes. In this Review, we provide an updated overview of glutamine metabolism and its involvement in tumorigenesis in vitro and in vivo, and explore the recent potential applications of basic science discoveries in the clinical setting.

Original languageEnglish (US)
JournalNature Reviews Cancer
DOIs
StateAccepted/In press - Jul 29 2016
Externally publishedYes

Fingerprint

Glutamine
Food
Neoplasms
Glycolysis
Carcinogenesis
Therapeutics
Glucose
Research

ASJC Scopus subject areas

  • Medicine(all)
  • Oncology
  • Cancer Research

Cite this

From Krebs to clinic : glutamine metabolism to cancer therapy. / Altman, Brian J.; Stine, Zachary E.; Dang, Chi V.

In: Nature Reviews Cancer, 29.07.2016.

Research output: Contribution to journalArticle

Altman, Brian J. ; Stine, Zachary E. ; Dang, Chi V. / From Krebs to clinic : glutamine metabolism to cancer therapy. In: Nature Reviews Cancer. 2016.
@article{a5d122092b0c49b2b2f5752619faa387,
title = "From Krebs to clinic: glutamine metabolism to cancer therapy",
abstract = "The resurgence of research into cancer metabolism has recently broadened interests beyond glucose and the Warburg effect to other nutrients, including glutamine. Because oncogenic alterations of metabolism render cancer cells addicted to nutrients, pathways involved in glycolysis or glutaminolysis could be exploited for therapeutic purposes. In this Review, we provide an updated overview of glutamine metabolism and its involvement in tumorigenesis in vitro and in vivo, and explore the recent potential applications of basic science discoveries in the clinical setting.",
author = "Altman, {Brian J.} and Stine, {Zachary E.} and Dang, {Chi V.}",
year = "2016",
month = "7",
day = "29",
doi = "10.1038/nrc.2016.71",
language = "English (US)",
journal = "Nature Reviews Cancer",
issn = "1474-175X",
publisher = "Nature Publishing Group",

}

TY - JOUR

T1 - From Krebs to clinic

T2 - glutamine metabolism to cancer therapy

AU - Altman, Brian J.

AU - Stine, Zachary E.

AU - Dang, Chi V.

PY - 2016/7/29

Y1 - 2016/7/29

N2 - The resurgence of research into cancer metabolism has recently broadened interests beyond glucose and the Warburg effect to other nutrients, including glutamine. Because oncogenic alterations of metabolism render cancer cells addicted to nutrients, pathways involved in glycolysis or glutaminolysis could be exploited for therapeutic purposes. In this Review, we provide an updated overview of glutamine metabolism and its involvement in tumorigenesis in vitro and in vivo, and explore the recent potential applications of basic science discoveries in the clinical setting.

AB - The resurgence of research into cancer metabolism has recently broadened interests beyond glucose and the Warburg effect to other nutrients, including glutamine. Because oncogenic alterations of metabolism render cancer cells addicted to nutrients, pathways involved in glycolysis or glutaminolysis could be exploited for therapeutic purposes. In this Review, we provide an updated overview of glutamine metabolism and its involvement in tumorigenesis in vitro and in vivo, and explore the recent potential applications of basic science discoveries in the clinical setting.

UR - http://www.scopus.com/inward/record.url?scp=84982993825&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84982993825&partnerID=8YFLogxK

U2 - 10.1038/nrc.2016.71

DO - 10.1038/nrc.2016.71

M3 - Article

C2 - 27492215

AN - SCOPUS:84982993825

JO - Nature Reviews Cancer

JF - Nature Reviews Cancer

SN - 1474-175X

ER -