FRMA ST: Frozen robust multiarray analysis for Affymetrix Exon and Gene ST arrays

Matthew N. McCall, Harris A. Jaffee, Rafael A. Irizarry

Research output: Contribution to journalArticlepeer-review

Abstract

Frozen robust multiarray analysis (fRMA) is a single-array preprocessing algorithm that retains the advantages of multiarray algorithms and removes certain batch effects by downweighting probes that have high between-batch residual variance. Here, we extend the fRMA algorithm to two new microarray platforms-Affymetrix Human Exon and Gene 1.0 ST-by modifying the fRMA probe-level model and extending the frma package to work with oligo ExonFeatureSet and GeneFeatureSet objects.

Original languageEnglish (US)
Pages (from-to)3153-3154
Number of pages2
JournalBioinformatics
Volume28
Issue number23
DOIs
StatePublished - Dec 2012

ASJC Scopus subject areas

  • Statistics and Probability
  • Biochemistry
  • Molecular Biology
  • Computer Science Applications
  • Computational Theory and Mathematics
  • Computational Mathematics

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