Frizzled6 controls hair patterning in mice

Nini Guo, Charles Hawkins, Jeremy Nathans

Research output: Contribution to journalArticlepeer-review

222 Scopus citations


Hair whorls and other macroscopic hair patterns are found in a variety of mammalian species, including humans. We show here that Frizzled6 (Fz6), one member of a large family of integral membrane Wnt receptors, controls macroscopic hair patterning in the mouse. Fz6 is expressed in the skin and hair follicles, and targeted deletion of the Fz6 gene produces stereotyped whorls on the hind feet, variable whorls and tufts on the head, and misorientation of hairs on the torso. Embryo chimera experiments imply that Fz6 acts locally to control or propagate the macroscopic hair pattern and that epithelial cells rather than melanocytes are the source of Fz6-dependent signaling. The Fz6 phenotype strongly resembles the wing-hair and bristle patterning defects observed in Drosophila frizzled mutants. These data imply that hair patterning in mammals uses a Fz-dependent tissue polarity system similar to the one that patterns the Drosophila cuticle.

Original languageEnglish (US)
Pages (from-to)9277-9281
Number of pages5
JournalProceedings of the National Academy of Sciences of the United States of America
Issue number25
StatePublished - Jun 22 2004

ASJC Scopus subject areas

  • General


Dive into the research topics of 'Frizzled6 controls hair patterning in mice'. Together they form a unique fingerprint.

Cite this