FRET-based activity biosensors to probe compartmentalized signaling

Xinxin Gao, Jin Zhang

Research output: Contribution to journalArticlepeer-review

Abstract

Illuminating compartmentalized signaling: We discuss the applications of FRET-based biosensors with a focus on understanding compartmentalized signaling of kinase and second-messenger dynamics. With their unique features of genetic encodability and targetability, these biosensors allow real-time tracking of activity dynamics with high spatiotemporal resolution. (Figure Presented).

Original languageEnglish (US)
Pages (from-to)147-151
Number of pages5
JournalChemBioChem
Volume11
Issue number2
DOIs
StatePublished - Jan 25 2010

Keywords

  • Biosensors
  • FRET
  • Kinases
  • Second messenger
  • Signaling compartmentation

ASJC Scopus subject areas

  • Biochemistry
  • Organic Chemistry
  • Molecular Medicine
  • Molecular Biology

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