FRET-based activity biosensors to probe compartmentalized signaling

Xinxin Gao; Jin Zhang

doi:10.1002/cbic.200900594

FRET-based activity biosensors to probe compartmentalized signaling

Xinxin Gao, Jin Zhang

School of Medicine

Research output: Contribution to journal › Article › peer-review

11 Scopus citations

Abstract

Illuminating compartmentalized signaling: We discuss the applications of FRET-based biosensors with a focus on understanding compartmentalized signaling of kinase and second-messenger dynamics. With their unique features of genetic encodability and targetability, these biosensors allow real-time tracking of activity dynamics with high spatiotemporal resolution. (Figure Presented).

Original language	English (US)
Pages (from-to)	147-151
Number of pages	5
Journal	ChemBioChem
Volume	11
Issue number	2
DOIs	https://doi.org/10.1002/cbic.200900594
State	Published - Jan 25 2010

Keywords

Biosensors
FRET
Kinases
Second messenger
Signaling compartmentation

ASJC Scopus subject areas

Biochemistry
Organic Chemistry
Molecular Medicine
Molecular Biology

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10.1002/cbic.200900594

Cite this

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abstract = "Illuminating compartmentalized signaling: We discuss the applications of FRET-based biosensors with a focus on understanding compartmentalized signaling of kinase and second-messenger dynamics. With their unique features of genetic encodability and targetability, these biosensors allow real-time tracking of activity dynamics with high spatiotemporal resolution. (Figure Presented).",

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KW - Kinases

KW - Second messenger

KW - Signaling compartmentation

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FRET-based activity biosensors to probe compartmentalized signaling

Abstract

Keywords

ASJC Scopus subject areas

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