Frequent truncating mutations of STAG2 in bladder cancer

David A. Solomon; Jung Sik Kim; Jolanta Bondaruk; Shahrokh F. Shariat; Zeng Feng Wang; Abdel G. Elkahloun; Tomoko Ozawa; Julia Gerard; Dazhong Zhuang; Shizhen Zhang; Neema Navai; Arlene Siefker-Radtke; Joanna J. Phillips; Brian D. Robinson; Mark A. Rubin; Björn Volkmer; Richard Hautmann; Rainer Küfer; Pancras C.W. Hogendoorn; George Netto; Dan Theodorescu; C. David James; Bogdan Czerniak; Markku Miettinen; Todd Waldman

doi:10.1038/ng.2800

Frequent truncating mutations of STAG2 in bladder cancer

David A. Solomon, Jung Sik Kim, Jolanta Bondaruk, Shahrokh F. Shariat, Zeng Feng Wang, Abdel G. Elkahloun, Tomoko Ozawa, Julia Gerard, Dazhong Zhuang, Shizhen Zhang, Neema Navai, Arlene Siefker-Radtke, Joanna J. Phillips, Brian D. Robinson, Mark A. Rubin, Björn Volkmer, Richard Hautmann, Rainer Küfer, Pancras C.W. Hogendoorn, George NettoDan Theodorescu, C. David James, Bogdan Czerniak, Markku Miettinen, Todd Waldman

Research output: Contribution to journal › Article › peer-review

128 Scopus citations

Abstract

Here we report the discovery of truncating mutations of the gene encoding the cohesin subunit STAG2, which regulates sister chromatid cohesion and segregation, in 36% of papillary non-invasive urothelial carcinomas and 16% of invasive urothelial carcinomas of the bladder. Our studies suggest that STAG2 has a role in controlling chromosome number but not the proliferation of bladder cancer cells. These findings identify STAG2 as one of the most commonly mutated genes in bladder cancer.

Original language	English (US)
Pages (from-to)	1428-1430
Number of pages	3
Journal	Nature genetics
Volume	45
Issue number	12
DOIs	https://doi.org/10.1038/ng.2800
State	Published - Dec 2013
Externally published	Yes

ASJC Scopus subject areas

Genetics

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Solomon, D. A., Kim, J. S., Bondaruk, J., Shariat, S. F., Wang, Z. F., Elkahloun, A. G., Ozawa, T., Gerard, J., Zhuang, D., Zhang, S., Navai, N., Siefker-Radtke, A., Phillips, J. J., Robinson, B. D., Rubin, M. A., Volkmer, B., Hautmann, R., Küfer, R., Hogendoorn, P. C. W., ... Waldman, T. (2013). Frequent truncating mutations of STAG2 in bladder cancer. Nature genetics, 45(12), 1428-1430. https://doi.org/10.1038/ng.2800

Solomon, DA, Kim, JS, Bondaruk, J, Shariat, SF, Wang, ZF, Elkahloun, AG, Ozawa, T, Gerard, J, Zhuang, D, Zhang, S, Navai, N, Siefker-Radtke, A, Phillips, JJ, Robinson, BD, Rubin, MA, Volkmer, B, Hautmann, R, Küfer, R, Hogendoorn, PCW, Netto, G, Theodorescu, D, James, CD, Czerniak, B, Miettinen, M & Waldman, T 2013, 'Frequent truncating mutations of STAG2 in bladder cancer', Nature genetics, vol. 45, no. 12, pp. 1428-1430. https://doi.org/10.1038/ng.2800

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title = "Frequent truncating mutations of STAG2 in bladder cancer",

abstract = "Here we report the discovery of truncating mutations of the gene encoding the cohesin subunit STAG2, which regulates sister chromatid cohesion and segregation, in 36% of papillary non-invasive urothelial carcinomas and 16% of invasive urothelial carcinomas of the bladder. Our studies suggest that STAG2 has a role in controlling chromosome number but not the proliferation of bladder cancer cells. These findings identify STAG2 as one of the most commonly mutated genes in bladder cancer.",

author = "Solomon, {David A.} and Kim, {Jung Sik} and Jolanta Bondaruk and Shariat, {Shahrokh F.} and Wang, {Zeng Feng} and Elkahloun, {Abdel G.} and Tomoko Ozawa and Julia Gerard and Dazhong Zhuang and Shizhen Zhang and Neema Navai and Arlene Siefker-Radtke and Phillips, {Joanna J.} and Robinson, {Brian D.} and Rubin, {Mark A.} and Bj{\"o}rn Volkmer and Richard Hautmann and Rainer K{\"u}fer and Hogendoorn, {Pancras C.W.} and George Netto and Dan Theodorescu and James, {C. David} and Bogdan Czerniak and Markku Miettinen and Todd Waldman",

note = "Funding Information: We thank B. Vogelstein for assistance in acquiring samples and preparing genomic DNA. This work was supported by US National Institutes of Health grants R01CA169345, R01CA159467 and R21CA143282 to T.W., by the MD Anderson Cancer Center Bladder Cancer SPORE grant P50CA091846 and by the Intramural Research Program of the National Human Genome Research Institute, US National Institutes of Health.",

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doi = "10.1038/ng.2800",

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AU - Solomon, David A.

AU - Kim, Jung Sik

AU - Bondaruk, Jolanta

AU - Shariat, Shahrokh F.

AU - Wang, Zeng Feng

AU - Elkahloun, Abdel G.

AU - Ozawa, Tomoko

AU - Gerard, Julia

AU - Zhuang, Dazhong

AU - Zhang, Shizhen

AU - Navai, Neema

AU - Siefker-Radtke, Arlene

AU - Phillips, Joanna J.

AU - Robinson, Brian D.

AU - Rubin, Mark A.

AU - Volkmer, Björn

AU - Hautmann, Richard

AU - Küfer, Rainer

AU - Hogendoorn, Pancras C.W.

AU - Netto, George

AU - Theodorescu, Dan

AU - James, C. David

AU - Czerniak, Bogdan

AU - Miettinen, Markku

AU - Waldman, Todd

N1 - Funding Information: We thank B. Vogelstein for assistance in acquiring samples and preparing genomic DNA. This work was supported by US National Institutes of Health grants R01CA169345, R01CA159467 and R21CA143282 to T.W., by the MD Anderson Cancer Center Bladder Cancer SPORE grant P50CA091846 and by the Intramural Research Program of the National Human Genome Research Institute, US National Institutes of Health.

PY - 2013/12

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AB - Here we report the discovery of truncating mutations of the gene encoding the cohesin subunit STAG2, which regulates sister chromatid cohesion and segregation, in 36% of papillary non-invasive urothelial carcinomas and 16% of invasive urothelial carcinomas of the bladder. Our studies suggest that STAG2 has a role in controlling chromosome number but not the proliferation of bladder cancer cells. These findings identify STAG2 as one of the most commonly mutated genes in bladder cancer.

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Frequent truncating mutations of STAG2 in bladder cancer

Abstract

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