Frequent low doses of intravenous mechlorethamine for late stage mycosis fungoides lymphoma

E. J. van Scott, D. A. Grekin, J. D. Kalmanson, E. C. Vonderheid, W. E. Barry

Research output: Contribution to journalArticlepeer-review

Abstract

Ninety two courses of daily low dose intravenous nitrogen mustard were administered to 46 patients with advanced cutaneous lymphomas (mycosis fungoides, Sezary syndrome and lymphoma cutis). Seventy eight per cent of patients showed objective clinical remission, and 35% reached a clinically disease free state following 1 or more courses. The response rate was greater in patients with the plaque tumor type of mycosis fungoides than in those with erythrodermic variants. Therapy was free of significant side effects.

Original languageEnglish (US)
Pages (from-to)1613-1618
Number of pages6
JournalCancer
Volume36
Issue number5
DOIs
StatePublished - 1975
Externally publishedYes

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

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