Frequent Loss of Heterozygosity at the Retinoblastoma Locus in Human Esophageal Cancers

Robert F. Boynton; Jing Yin; Tim McDaniel; Stephen J. Meltzer; Ying Huang; Carnell Newkirk; James H. Resau; Stephen J. Meltzer; Patricia L. Blount; Brian J. Reid; Wendy H. Raskind; Rodger C. Haggitt

Frequent Loss of Heterozygosity at the Retinoblastoma Locus in Human Esophageal Cancers

Robert F. Boynton, Jing Yin, Tim McDaniel, Stephen J. Meltzer, Ying Huang, Carnell Newkirk, James H. Resau, Stephen J. Meltzer, Patricia L. Blount, Brian J. Reid, Wendy H. Raskind, Rodger C. Haggitt

Research output: Contribution to journal › Article › peer-review

132 Scopus citations

Abstract

Abnormalities in the retinoblastoma tumor suppressor gene (Rb) have been observed in a large number of human cancers. Loss of heterozygosity is a common mode of allelic inactivation of Rb and other tumor suppressor genes. We investigated DNA from 61 primary human esophageal tumors for loss of heterozygosity at the Rb locus using a polymerase chain reaction-based restriction fragment length polymorphism assay. Of informative cases, we found loss of heterozygosity in 14 of 26 (54%) squamous cell carcinomas and 5 of 14 (36%) adenocarcinomas. These data support the hypothesis that Rb inactivation is involved in the pathogenesis and/or progression of esophageal cancer.

Original language	English (US)
Pages (from-to)	5766-5769
Number of pages	4
Journal	Cancer Research
Volume	51
Issue number	20
State	Published - Oct 1991
Externally published	Yes

ASJC Scopus subject areas

Oncology
Cancer Research

Cite this

@article{f3731c4824be4226901c42e4930e955d,

title = "Frequent Loss of Heterozygosity at the Retinoblastoma Locus in Human Esophageal Cancers",

abstract = "Abnormalities in the retinoblastoma tumor suppressor gene (Rb) have been observed in a large number of human cancers. Loss of heterozygosity is a common mode of allelic inactivation of Rb and other tumor suppressor genes. We investigated DNA from 61 primary human esophageal tumors for loss of heterozygosity at the Rb locus using a polymerase chain reaction-based restriction fragment length polymorphism assay. Of informative cases, we found loss of heterozygosity in 14 of 26 (54%) squamous cell carcinomas and 5 of 14 (36%) adenocarcinomas. These data support the hypothesis that Rb inactivation is involved in the pathogenesis and/or progression of esophageal cancer.",

author = "Boynton, {Robert F.} and Jing Yin and Tim McDaniel and Meltzer, {Stephen J.} and Ying Huang and Carnell Newkirk and Resau, {James H.} and Meltzer, {Stephen J.} and Blount, {Patricia L.} and Reid, {Brian J.} and Raskind, {Wendy H.} and Haggitt, {Rodger C.}",

year = "1991",

month = oct,

language = "English (US)",

volume = "51",

pages = "5766--5769",

journal = "Cancer Research",

issn = "0008-5472",

publisher = "American Association for Cancer Research Inc.",

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TY - JOUR

T1 - Frequent Loss of Heterozygosity at the Retinoblastoma Locus in Human Esophageal Cancers

AU - Boynton, Robert F.

AU - Yin, Jing

AU - McDaniel, Tim

AU - Meltzer, Stephen J.

AU - Huang, Ying

AU - Newkirk, Carnell

AU - Resau, James H.

AU - Meltzer, Stephen J.

AU - Blount, Patricia L.

AU - Reid, Brian J.

AU - Raskind, Wendy H.

AU - Haggitt, Rodger C.

PY - 1991/10

Y1 - 1991/10

N2 - Abnormalities in the retinoblastoma tumor suppressor gene (Rb) have been observed in a large number of human cancers. Loss of heterozygosity is a common mode of allelic inactivation of Rb and other tumor suppressor genes. We investigated DNA from 61 primary human esophageal tumors for loss of heterozygosity at the Rb locus using a polymerase chain reaction-based restriction fragment length polymorphism assay. Of informative cases, we found loss of heterozygosity in 14 of 26 (54%) squamous cell carcinomas and 5 of 14 (36%) adenocarcinomas. These data support the hypothesis that Rb inactivation is involved in the pathogenesis and/or progression of esophageal cancer.

AB - Abnormalities in the retinoblastoma tumor suppressor gene (Rb) have been observed in a large number of human cancers. Loss of heterozygosity is a common mode of allelic inactivation of Rb and other tumor suppressor genes. We investigated DNA from 61 primary human esophageal tumors for loss of heterozygosity at the Rb locus using a polymerase chain reaction-based restriction fragment length polymorphism assay. Of informative cases, we found loss of heterozygosity in 14 of 26 (54%) squamous cell carcinomas and 5 of 14 (36%) adenocarcinomas. These data support the hypothesis that Rb inactivation is involved in the pathogenesis and/or progression of esophageal cancer.

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AN - SCOPUS:0025936025

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JF - Cancer Research

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ER -

Frequent Loss of Heterozygosity at the Retinoblastoma Locus in Human Esophageal Cancers

Abstract

ASJC Scopus subject areas

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