Frequent loss of heterozygosity at the retinoblastoma locus in human esophageal cancers

Robert F. Boynton, Ying Huang, Patricia L. Blount, Stephen Meltzer, Wendy H. Raskind, Rodger C. Haggitt, Carnell Newkirk, James H. Resau, Jing Yin, Tim McDaniel, Stephen J. Meltzer

Research output: Contribution to journalArticle

Abstract

Abnormalities in the retinoblastoma tumor suppressor gene (Rb) have been observed in a large number of human cancers. Loss of heterozygosity is a common mode of allelic inactivation of Rb and other tumor suppressor genes. We investigated DNA from 61 primary human esophageal tumors for loss of heterozygosity at the Rb locus using a polymerase chain reaction-based restriction fragment length polymorphism assay. Of informative cases, we found loss of heterozygosity in 14 of 26 (54%) squamous cell carcinomas and 5 of 14 (36%) adenocarcinomas. These data support the hypothesis that Rb inactivation is involved in the pathogenesis and/or progression of esophageal cancer.

Original languageEnglish (US)
Pages (from-to)5766-5769
Number of pages4
JournalCancer Research
Volume51
Issue number20
StatePublished - Oct 15 1991
Externally publishedYes

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Retinoblastoma
Loss of Heterozygosity
Esophageal Neoplasms
Tumor Suppressor Genes
Restriction Fragment Length Polymorphisms
Squamous Cell Carcinoma
Neoplasms
Adenocarcinoma
Polymerase Chain Reaction
DNA

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Boynton, R. F., Huang, Y., Blount, P. L., Meltzer, S., Raskind, W. H., Haggitt, R. C., ... Meltzer, S. J. (1991). Frequent loss of heterozygosity at the retinoblastoma locus in human esophageal cancers. Cancer Research, 51(20), 5766-5769.

Frequent loss of heterozygosity at the retinoblastoma locus in human esophageal cancers. / Boynton, Robert F.; Huang, Ying; Blount, Patricia L.; Meltzer, Stephen; Raskind, Wendy H.; Haggitt, Rodger C.; Newkirk, Carnell; Resau, James H.; Yin, Jing; McDaniel, Tim; Meltzer, Stephen J.

In: Cancer Research, Vol. 51, No. 20, 15.10.1991, p. 5766-5769.

Research output: Contribution to journalArticle

Boynton, RF, Huang, Y, Blount, PL, Meltzer, S, Raskind, WH, Haggitt, RC, Newkirk, C, Resau, JH, Yin, J, McDaniel, T & Meltzer, SJ 1991, 'Frequent loss of heterozygosity at the retinoblastoma locus in human esophageal cancers', Cancer Research, vol. 51, no. 20, pp. 5766-5769.
Boynton RF, Huang Y, Blount PL, Meltzer S, Raskind WH, Haggitt RC et al. Frequent loss of heterozygosity at the retinoblastoma locus in human esophageal cancers. Cancer Research. 1991 Oct 15;51(20):5766-5769.
Boynton, Robert F. ; Huang, Ying ; Blount, Patricia L. ; Meltzer, Stephen ; Raskind, Wendy H. ; Haggitt, Rodger C. ; Newkirk, Carnell ; Resau, James H. ; Yin, Jing ; McDaniel, Tim ; Meltzer, Stephen J. / Frequent loss of heterozygosity at the retinoblastoma locus in human esophageal cancers. In: Cancer Research. 1991 ; Vol. 51, No. 20. pp. 5766-5769.
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