Frequent Isolation of HIV-1 from the Blood of Patients Receiving Zidovudine (AZT) Therapy

Donald S. Burke; Robert R. Redfield; Darrel C. Bjornson; Arnold K. Fowler; Charles N. Oster

doi:10.1056/NEJM198912143212414

Frequent Isolation of HIV-1 from the Blood of Patients Receiving Zidovudine (AZT) Therapy

Donald S. Burke, Robert R. Redfield, Darrel C. Bjornson, Arnold K. Fowler, Charles N. Oster

Bloomberg School of Public Health

Research output: Contribution to journal › Letter › peer-review

10 Scopus citations

Abstract

To the Editor: Strains of HIV-1 that are relatively resistant to zidovudine (AZT) have been isolated from the blood of patients receiving therapy with that drug.¹ However, the relations between in vitro sensitivity or resistance of HIV-1 to zidovudine, in vivo HIV-1 viremia, and therapeutic efficacy are poorly understood. Since persistent viremia in patients receiving zidovudine may be evidence of drug resistance, we undertook a retrospective study of the diagnostic results from our virology laboratory to determine the rates of isolation of HIV-1 among such patients. The records of all patients who had received zidovudine through the pharmacy of the…

Original language	English (US)
Number of pages	1
Journal	New England Journal of Medicine
Volume	321
Issue number	24
DOIs	https://doi.org/10.1056/NEJM198912143212414
State	Published - Dec 14 1989

ASJC Scopus subject areas

General Medicine

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title = "Frequent Isolation of HIV-1 from the Blood of Patients Receiving Zidovudine (AZT) Therapy",

abstract = "To the Editor: Strains of HIV-1 that are relatively resistant to zidovudine (AZT) have been isolated from the blood of patients receiving therapy with that drug.1 However, the relations between in vitro sensitivity or resistance of HIV-1 to zidovudine, in vivo HIV-1 viremia, and therapeutic efficacy are poorly understood. Since persistent viremia in patients receiving zidovudine may be evidence of drug resistance, we undertook a retrospective study of the diagnostic results from our virology laboratory to determine the rates of isolation of HIV-1 among such patients. The records of all patients who had received zidovudine through the pharmacy of the…",

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AU - Burke, Donald S.

AU - Redfield, Robert R.

AU - Bjornson, Darrel C.

AU - Fowler, Arnold K.

AU - Oster, Charles N.

PY - 1989/12/14

Y1 - 1989/12/14

N2 - To the Editor: Strains of HIV-1 that are relatively resistant to zidovudine (AZT) have been isolated from the blood of patients receiving therapy with that drug.1 However, the relations between in vitro sensitivity or resistance of HIV-1 to zidovudine, in vivo HIV-1 viremia, and therapeutic efficacy are poorly understood. Since persistent viremia in patients receiving zidovudine may be evidence of drug resistance, we undertook a retrospective study of the diagnostic results from our virology laboratory to determine the rates of isolation of HIV-1 among such patients. The records of all patients who had received zidovudine through the pharmacy of the…

AB - To the Editor: Strains of HIV-1 that are relatively resistant to zidovudine (AZT) have been isolated from the blood of patients receiving therapy with that drug.1 However, the relations between in vitro sensitivity or resistance of HIV-1 to zidovudine, in vivo HIV-1 viremia, and therapeutic efficacy are poorly understood. Since persistent viremia in patients receiving zidovudine may be evidence of drug resistance, we undertook a retrospective study of the diagnostic results from our virology laboratory to determine the rates of isolation of HIV-1 among such patients. The records of all patients who had received zidovudine through the pharmacy of the…

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Frequent Isolation of HIV-1 from the Blood of Patients Receiving Zidovudine (AZT) Therapy

Abstract

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